CALCIUM TURNOVER STUDIES IN MAN

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Methods for determination of calcium turnover in man with radioisotopes are presented and the clinical use of various techniques is evaluated. In the discussion of kinetic analyses, some important observations were made. The accretion rate calculation can be made independent of the number of compartments in the exchangeable calcium pool, and thus is not distorted by approximate estimations of this pool. However, if the exchangeable calcium pool is calculated with the isotope dilution technique, and the accretion rate obtained from this value by the total turnover equation, then an error is introduced into the value of the accretion rate. It ... continued below

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Pages: 29

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Corey, K R; Weber, D; Merlino, M; Greebberg, D; Kenny, P & Laughlin, J S January 1, 1963.

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Description

Methods for determination of calcium turnover in man with radioisotopes are presented and the clinical use of various techniques is evaluated. In the discussion of kinetic analyses, some important observations were made. The accretion rate calculation can be made independent of the number of compartments in the exchangeable calcium pool, and thus is not distorted by approximate estimations of this pool. However, if the exchangeable calcium pool is calculated with the isotope dilution technique, and the accretion rate obtained from this value by the total turnover equation, then an error is introduced into the value of the accretion rate. It was also pointed out that the multicompartment treatment is more appropriate than the customary single compartment analysis and utilizes all available information. Since the pool size has been of little clinical use so far, it was suggested that multicompantment analyses be used in the future. At present, no accepted model exists which can account for all data obtained in tracer studies and in particular for the last part of the serum disappearance curve. Preliminary results of long term studies of the retention in bones of strontium-85 was presented. These show that there is measurable turnover of tracer deposited in bone even several months after injection. (auth)

Physical Description

Pages: 29

Source

  • Symposium in Medicine, Dynamic Clinical Studies with Radiosotopes - Oak Ridge, Tennessee - October 21 - 25, 1963

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  • Report No.: CONF-355-4
  • Grant Number: AT(30-1)-910
  • Office of Scientific & Technical Information Report Number: 4094191
  • Archival Resource Key: ark:/67531/metadc863285

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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • January 1, 1963

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  • Sept. 16, 2016, 12:32 a.m.

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  • Oct. 31, 2016, 12:30 p.m.

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Corey, K R; Weber, D; Merlino, M; Greebberg, D; Kenny, P & Laughlin, J S. CALCIUM TURNOVER STUDIES IN MAN, article, January 1, 1963; United States. (digital.library.unt.edu/ark:/67531/metadc863285/: accessed December 15, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.