Response of the mouse fetus to radiation from Na/sup 99m/TcO$sub 4$

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The element technetium has recently assumed ecological importance as a source of low-level radiation, with the use of /sup 99m/Tc in nuclear medicine and production of /sup 99m/Tc during generation of electricity by nuclear reaction. When technetium is introduced as pertechnetate into the blood stream of pregnant females, it is transported across the placental barrier to the fetus, where a portion appears to be incorporated into biomolecules. When combined as biomolecules, radionuclides that decay by electron capture or isomeric transition show a lethality greater than that predicted in cell cultures and radiation therapy. The decay of /sup 99m/Tc by isomeric ... continued below

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16 p.

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Lathrop, K.A.; Gloria, I.V. & Harper, P.V. January 1, 1975.

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Description

The element technetium has recently assumed ecological importance as a source of low-level radiation, with the use of /sup 99m/Tc in nuclear medicine and production of /sup 99m/Tc during generation of electricity by nuclear reaction. When technetium is introduced as pertechnetate into the blood stream of pregnant females, it is transported across the placental barrier to the fetus, where a portion appears to be incorporated into biomolecules. When combined as biomolecules, radionuclides that decay by electron capture or isomeric transition show a lethality greater than that predicted in cell cultures and radiation therapy. The decay of /sup 99m/Tc by isomeric transition, together with the other considerations, places a high priority on the investigation of its radiation effects due to clinical doses of up to 25 mCi. Female mice were given daily i.v. injections of 0, 5, 50, and 500 $mu$ Ci of /sup 99m/Tc as pertechnetate in isotonic saline throughout gestation, gestation and lactation, or lactation. At two months of age, the progeny were mated with randomly selected litter mates to produce a second generation; the process was repeated with their progeny for production of the third generation.Preliminary results reinforce the existing concern about use of /sup 99m/Tc-pertechnetate in pregnant or potentially pregnant subjects. (auth)

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16 p.

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Dep. NTIS

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  • IAEA international symposium on biological effects of low level radiation pertinent to protection of man and his environment, Chicago, Illinois, USA, 3 Nov 1975

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  • Report No.: CONF-751126--6
  • Report No.: SM--202/416
  • Grant Number: E(11-1)-69
  • Office of Scientific & Technical Information Report Number: 4160949
  • Archival Resource Key: ark:/67531/metadc863169

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 1, 1975

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  • Sept. 16, 2016, 12:32 a.m.

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  • Oct. 12, 2017, 2:10 p.m.

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Lathrop, K.A.; Gloria, I.V. & Harper, P.V. Response of the mouse fetus to radiation from Na/sup 99m/TcO$sub 4$, article, January 1, 1975; United States. (digital.library.unt.edu/ark:/67531/metadc863169/: accessed December 11, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.