Acetylcholine-Containing Neuroepithelial Cells in Fish Gills Support the Cholinergic Hypothesis of O2 Chemoreception Metadata
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- Main Title Acetylcholine-Containing Neuroepithelial Cells in Fish Gills Support the Cholinergic Hypothesis of O2 Chemoreception
- Series Title University Scholars Day
Author: Wanner, ClintonCreator Type: PersonalCreator Info: University of North Texas
Contributor: Burleson, Mark L.Creator Type: PersonalCreator Info: University of North Texas; Faculty Mentor; email@example.com
Sponsor: University of North Texas. Honors College.Contributor Type: Organization
Name: University of North Texas. Honors College.Place of Publication: [Denton, Texas]
- Creation: 2011-04-14
- Embargoed Until: 2013-04-14
- Content Description: This paper discusses research on how acetylcholine-containing neuroepithelial cells in fish gills support the cholinergic hypothesis of O2 chemoreception.
- Physical Description: 15 p.
- Keyword: O2 chemoreceptors
- Keyword: neurotransmitters
- Keyword: fish gills
- Journal: The Eagle Feather, 2011, Denton: University of North Texas. Honors College
- Publication Title: The Eagle Feather
- Issue: 2011
- Volume: 8
- Peer Reviewed: True
- Is Version Of: Acetylcholine-Containing Neuroepithelial Cells in Fish Gills Support the Cholinergic Hypothesis of O2 Chemoreception [Presentation], ark:/67531/metadc93292
Name: UNT Scholarly WorksCode: UNTSW
Name: UNT Honors CollegeCode: UNTHON
- Rights Access: public
- DOI: 10.12794/tef.2011.248
- Archival Resource Key: ark:/67531/metadc86190
- Academic Department: Biological Sciences
- Embargo Note: This item has a 2 year embargo period. For more information on this item or to inquire about obtaining a copy, please contact the authors directly.
- Display Note: Abstract: The neurochemical link between O2 chemoreceptors and afferent nerves that carry information about O2 levels to cardio-ventilatory centers in the brain has yet to be determined. This study examines the roles of two candidate neurotransmitters thought to be involved in O2 chemoreception, using channel catfish, Ictalurus punctatus. Fish gills are the evolutionary progenitors of arterial arches (aortic and carotid) of mammals where O2 chemoreceptors are located. Neuroepithelial cells (NECs) containing serotonin (5-HT) and acetylcholine (Ach) were confirmed in the first gill arch using immunohistochemistry and laser confocal microscopy. 5-HT-containing NECs were aggregated around the efferent branchial artery, near tips of filaments and lamellae, ACh-containing NECs at the distal tips of filaments. Preliminary co-localization experiments indicate separate 5-HT and Ach-containing cells. This is the first demonstration of ACh-containing NECs and results of this study support pharmacological studies suggesting that ACh is the primary neurochemical involved in O2 chemoreception in vertebrates.
- Display Note: Eighth Annual University Scholars Day, 2011, Denton, Texas, United States.