Design of New Monodentate Ligands for Regioselectivity and Enantioselectivity Tuning in Late Transition Metal Catalysis

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The ability of gold(I) to activate many types of unsaturated bonds toward nucleophilic attack was not widely recognized until the early 2000s. One major challenge in gold catalysis is the control over regioselectivity when there are two or more possible products as a result of complicated mechanistic pathways. It is well know that the choice of ligand can have dramatic effects on which pathway is being followed but very rarely are the reasons for this selectivity understood. The synthesis of new acyclic diaminocarbenes was developed and a study of the ligand effects on the regioselectivity of a gold-catalyzed domino enyne ... continued below

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Ruch, Aaron Anthony May 2016.

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  • Ruch, Aaron Anthony

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The ability of gold(I) to activate many types of unsaturated bonds toward nucleophilic attack was not widely recognized until the early 2000s. One major challenge in gold catalysis is the control over regioselectivity when there are two or more possible products as a result of complicated mechanistic pathways. It is well know that the choice of ligand can have dramatic effects on which pathway is being followed but very rarely are the reasons for this selectivity understood. The synthesis of new acyclic diaminocarbenes was developed and a study of the ligand effects on the regioselectivity of a gold-catalyzed domino enyne cyclization hydroarylation reaction and a Nazarov cyclization was undertaken. New chiral acyclic diaminocarbenes were also developed and tested along side new C3-symmetric phosphite ligands in an asymmetric intramolecular hydroamination of allenes. Structure activity correlations were developed for the potential use in further rational ligand design. The synthesis of 6a,7-dihydro-5-amino-dibenzo[c,g]chromene derivatives via a gold-catalyzed domino reaction of alkynylbenzaldehydes in the presence of secondary amines was developed. These were sent to be screened for biological activity.

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  • May 2016

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  • June 28, 2016, 4:28 p.m.

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  • July 25, 2016, 1:06 p.m.

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Ruch, Aaron Anthony. Design of New Monodentate Ligands for Regioselectivity and Enantioselectivity Tuning in Late Transition Metal Catalysis, dissertation, May 2016; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc849723/: accessed June 23, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .