A hierarchy of ECM-mediated signalling tissue-specific gene expression regulates tissue-specific gene expression

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A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hierarchies whose constituent inputs and outputs are constantly modulated by all the factors present in the cell's surrounding microenvironment. This is particularly evident in the mammary gland, where the construction and subsequent destruction of such a hierarchy regulates changes in tissue-specific gene expression, morphogenesis and apoptosis during each developmental cycle of pregnancy, lactation and ... continued below

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Roskelley, Calvin D; Srebrow, Anabella & Bissell, Mina J October 7, 1995.

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A dynamic and reciprocal flow of information between cells and the extracellular matrix contributes significantly to the regulation of form and function in developing systems. Signals generated by the extracellular matrix do not act in isolation. Instead, they are processed within the context of global signalling hierarchies whose constituent inputs and outputs are constantly modulated by all the factors present in the cell's surrounding microenvironment. This is particularly evident in the mammary gland, where the construction and subsequent destruction of such a hierarchy regulates changes in tissue-specific gene expression, morphogenesis and apoptosis during each developmental cycle of pregnancy, lactation and involution.

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736

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  • Journal Name: Current Opinion in Cell Biology; Journal Volume: 7; Journal Issue: 5; Related Information: Journal Publication Date: 10/1995

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  • Report No.: LBNL-4093E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: CA 57621-02
  • DOI: 10.1016/0955-0674(95)80117-0 | External Link
  • Office of Scientific & Technical Information Report Number: 1000967
  • Archival Resource Key: ark:/67531/metadc846920

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  • October 7, 1995

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  • May 19, 2016, 3:16 p.m.

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  • June 16, 2016, 12:38 p.m.

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Roskelley, Calvin D; Srebrow, Anabella & Bissell, Mina J. A hierarchy of ECM-mediated signalling tissue-specific gene expression regulates tissue-specific gene expression, article, October 7, 1995; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc846920/: accessed October 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.