Toxicology Studies on Lewisite and Sulfur Mustard Agents: Mutagenicity of Sulfur Mustard in the Salmonella Histidine Reversion Assay Final Report

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Description

The mutagenic potential of bis 2-chloroethyl sulfide (HD} a bifunctional sulfur mustard was evaluated in the standard plate incorporation version and the preincubation modification of the Salmonella/microsomal assay with tester strains TA97, TA98, TA100 and TA102, with and without 59 activation. HD-induced point mutations in strain TA102 and frameshift mutations in TA97 but showed little or no mutagenicity against strains TA98 and TA100. Extensive HD-induced cell killing was observed with the excision repair deficient strains (TA100, TA98 and TA97) but not with strain TA102, which is wild-activation by Aroc1or induced rat liver microsomes (S9).

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Stewart, D. L.; Sass, E. J.; Fritz, L. K. & Sasser, L. B. July 31, 1989.

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Description

The mutagenic potential of bis 2-chloroethyl sulfide (HD} a bifunctional sulfur mustard was evaluated in the standard plate incorporation version and the preincubation modification of the Salmonella/microsomal assay with tester strains TA97, TA98, TA100 and TA102, with and without 59 activation. HD-induced point mutations in strain TA102 and frameshift mutations in TA97 but showed little or no mutagenicity against strains TA98 and TA100. Extensive HD-induced cell killing was observed with the excision repair deficient strains (TA100, TA98 and TA97) but not with strain TA102, which is wild-activation by Aroc1or induced rat liver microsomes (S9).

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  • Report No.: PNL-6873
  • Grant Number: DE-AC06-76RL01830
  • DOI: 10.2172/1086509 | External Link
  • Office of Scientific & Technical Information Report Number: 1086509
  • Archival Resource Key: ark:/67531/metadc846621

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  • July 31, 1989

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  • May 19, 2016, 9:45 a.m.

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  • Dec. 2, 2016, 3:52 p.m.

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Stewart, D. L.; Sass, E. J.; Fritz, L. K. & Sasser, L. B. Toxicology Studies on Lewisite and Sulfur Mustard Agents: Mutagenicity of Sulfur Mustard in the Salmonella Histidine Reversion Assay Final Report, report, July 31, 1989; Richland, Washington. (digital.library.unt.edu/ark:/67531/metadc846621/: accessed August 24, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.