Quantitative Analysis of Clustered DNA Damages Induced by Silicon Beams of Different Kinetic Energy

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Humans may b exposed to highly energetic charged particle radiation as a result of medical treatments, occupational activitie or accidental events. In recent years, our increasing presence and burgeoning interest in space exploration beyond low Earth orbit has led to a large increase in the research of the biological effects ofcharged particle radiation typical of that encountered in the space radiation environment. The study of the effects of these types of radiation qualities in terms ofDNA damage induction and repair is fundamental to understand mechanisms both underlying their greater biological effectiveness as we)) as the short and long term risks ... continued below

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J., Keszenman D.; Keszenman, D.J.; Bennett, P.V.; Sutherland, B.M. & Wilson, P.F. May 14, 2013.

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Humans may b exposed to highly energetic charged particle radiation as a result of medical treatments, occupational activitie or accidental events. In recent years, our increasing presence and burgeoning interest in space exploration beyond low Earth orbit has led to a large increase in the research of the biological effects ofcharged particle radiation typical of that encountered in the space radiation environment. The study of the effects of these types of radiation qualities in terms ofDNA damage induction and repair is fundamental to understand mechanisms both underlying their greater biological effectiveness as we)) as the short and long term risks of health effects such as carcinogenesis, degen rative diseases and premature aging. Charged particle radiation induces a variety of DNA alterations, notably bistranded clustered damages, defined as two or more closely-opposed strand break , oxidized bases or abasic sites within a few helical turns. The induction of such highly complex DNA damage enhances the probability of incorrect or incomplete repair and thus constitutes greater potential for genomic instability, cell death and transformation.

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  • NASA Space Radiation Investigators’ Workshop and Heavy Ions in Therapy and Space Radiation Symposium; Chiba, Japan; 20130514 through 20130519

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  • Report No.: BNL--100620-2013-CP
  • Grant Number: DE-AC02-98CH10886
  • Office of Scientific & Technical Information Report Number: 1079890
  • Archival Resource Key: ark:/67531/metadc842800

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  • May 14, 2013

Added to The UNT Digital Library

  • May 19, 2016, 9:45 a.m.

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  • July 21, 2016, 6:28 p.m.

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J., Keszenman D.; Keszenman, D.J.; Bennett, P.V.; Sutherland, B.M. & Wilson, P.F. Quantitative Analysis of Clustered DNA Damages Induced by Silicon Beams of Different Kinetic Energy, article, May 14, 2013; United States. (digital.library.unt.edu/ark:/67531/metadc842800/: accessed October 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.