Development and Testing of a 212Pb/212Bi Peptide for Targeting Metastatic Melanoma

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The purpose of this project is to develop a new radiolabeled peptide for imaging and treating metastatic melanoma. The immunoconjugate consists of a receptor-specific peptide that targets melanoma cells. The beta-emitter lead-212 (half-life = 10.4 hours) is linked by coordination chemistry to the peptide. After injection, the peptide targets melanoma receptors on the surfaces of melanoma cells. Lead-212 decays to the alpha-emitter bismuth-212 (half-life = 60 minutes). Alpha-particles that hit melanoma cell nuclei are likely to kill the melanoma cell. For cancer cell imaging, the lead-212 is replaced by lead-203 (half-life = 52 hours). Lead-203 emits 279 keV photons (80.1% ... continued below

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Fisher, Darrell R. October 25, 2012.

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Description

The purpose of this project is to develop a new radiolabeled peptide for imaging and treating metastatic melanoma. The immunoconjugate consists of a receptor-specific peptide that targets melanoma cells. The beta-emitter lead-212 (half-life = 10.4 hours) is linked by coordination chemistry to the peptide. After injection, the peptide targets melanoma receptors on the surfaces of melanoma cells. Lead-212 decays to the alpha-emitter bismuth-212 (half-life = 60 minutes). Alpha-particles that hit melanoma cell nuclei are likely to kill the melanoma cell. For cancer cell imaging, the lead-212 is replaced by lead-203 (half-life = 52 hours). Lead-203 emits 279 keV photons (80.1% abundance) that can be imaged and measured for biodistribution analysis, cancer imaging, and quantitative dosimetry.

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  • Report No.: PNNL-21943
  • Grant Number: AC05-76RL01830
  • DOI: 10.2172/1054055 | External Link
  • Office of Scientific & Technical Information Report Number: 1054055
  • Archival Resource Key: ark:/67531/metadc840304

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Office of Scientific & Technical Information Technical Reports

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  • October 25, 2012

Added to The UNT Digital Library

  • May 19, 2016, 9:45 a.m.

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  • Dec. 7, 2016, 10:43 a.m.

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Fisher, Darrell R. Development and Testing of a 212Pb/212Bi Peptide for Targeting Metastatic Melanoma, report, October 25, 2012; Richland, Washington. (digital.library.unt.edu/ark:/67531/metadc840304/: accessed December 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.