ChIP-seq Mapping of Distant-Acting Enhancers and Their In Vivo Activities

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The genomic location and function of most distant-acting transcriptional enhancers in the human genome remains unknown We performed ChIP-seq for various transcriptional coactivator proteins (such as p300) directly from different embryonic mouse tissues, identifying thousands of binding sitesTransgenic mouse experiments show that p300 and other co-activator peaks are highly predictive of genomic location AND tissue-specific activity patterns of distant-acting enhancersMost enhancers are active only in one or very few tissues Genomic location of tissue-specific p300 peaks correlates with tissue-specific expression of nearby genes Most binding sites are conserved, but the global degree of conservation varies between tissues

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Visel, Axel & Pennacchio, Len A. June 1, 2011.

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The genomic location and function of most distant-acting transcriptional enhancers in the human genome remains unknown We performed ChIP-seq for various transcriptional coactivator proteins (such as p300) directly from different embryonic mouse tissues, identifying thousands of binding sitesTransgenic mouse experiments show that p300 and other co-activator peaks are highly predictive of genomic location AND tissue-specific activity patterns of distant-acting enhancersMost enhancers are active only in one or very few tissues Genomic location of tissue-specific p300 peaks correlates with tissue-specific expression of nearby genes Most binding sites are conserved, but the global degree of conservation varies between tissues

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  • Strategic BioSciences Review, Berkeley, CA, 4/26-27/2011

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  • Report No.: LBNL-4785E-Poster
  • Grant Number: DE-AC02-05CH11231
  • Office of Scientific & Technical Information Report Number: 1050657
  • Archival Resource Key: ark:/67531/metadc839130

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  • June 1, 2011

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  • May 19, 2016, 9:45 a.m.

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  • June 16, 2016, 1:22 p.m.

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Visel, Axel & Pennacchio, Len A. ChIP-seq Mapping of Distant-Acting Enhancers and Their In Vivo Activities, article, June 1, 2011; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc839130/: accessed April 27, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.