A systematic investigation of PET Radionuclide Specific Activity on Miniaturization of Radiochemistry

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The PET radionuclides, 18F and 11C consist of very high radiation to mass amounts and should be easily adapted to new technologies such as “chip chemistry” with nanofluidics. However, environmental contamination with nonradioactive fluorine, carbon and other trace contaminants add sufficient mass, micrograms to milligrams, to prevent adapting PET radiochemistry to the nanochip technologies. In addition, the large volumes of material required for beam irradiation make it necessary to also remove the 18F and 11C from their chemical matrices. These steps add contaminants. The work described in this report was a systematic investigation of sources of these contaminants and methods ... continued below

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Link, Jeanne M. March 8, 2012.

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Description

The PET radionuclides, 18F and 11C consist of very high radiation to mass amounts and should be easily adapted to new technologies such as “chip chemistry” with nanofluidics. However, environmental contamination with nonradioactive fluorine, carbon and other trace contaminants add sufficient mass, micrograms to milligrams, to prevent adapting PET radiochemistry to the nanochip technologies. In addition, the large volumes of material required for beam irradiation make it necessary to also remove the 18F and 11C from their chemical matrices. These steps add contaminants. The work described in this report was a systematic investigation of sources of these contaminants and methods to reduce these contaminants and the reaction volumes for radiochemical synthesis. Several methods were found to lower the contaminants and matrices to within a factor of 2 to 100 of those needed to fully implement chip technology but further improvements are needed.

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228 kb

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  • Report No.: DOE ER64668-2
  • Grant Number: FG02-08ER64668
  • DOI: 10.2172/1036014 | External Link
  • Office of Scientific & Technical Information Report Number: 1036014
  • Archival Resource Key: ark:/67531/metadc837017

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  • March 8, 2012

Added to The UNT Digital Library

  • May 19, 2016, 3:16 p.m.

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  • June 14, 2016, 9:47 p.m.

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Link, Jeanne M. A systematic investigation of PET Radionuclide Specific Activity on Miniaturization of Radiochemistry, report, March 8, 2012; United States. (digital.library.unt.edu/ark:/67531/metadc837017/: accessed July 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.