Gene Expression in the Third Dimension: The ECM-nucleus Connection

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Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell growth and tissue specific gene expression, the nuclear mechanisms through which these molecules promote these physiological events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function in the mammary gland.

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Spencer, Virginia A; Xu, Ren & Bissell, Mina October 1, 2009.

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Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell growth and tissue specific gene expression, the nuclear mechanisms through which these molecules promote these physiological events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function in the mammary gland.

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  • Journal Name: Journal Mammary Gland Biology Neoplasia; Journal Volume: 15; Journal Issue: 1; Related Information: Journal Publication Date: March 2010

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  • Report No.: LBNL-4099E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: DEAC02-05CH1123, R01CA064786, U54CA126552, U54CA112970, R01CA057621
  • Office of Scientific & Technical Information Report Number: 1000962
  • Archival Resource Key: ark:/67531/metadc835047

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • October 1, 2009

Added to The UNT Digital Library

  • May 19, 2016, 3:16 p.m.

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  • June 15, 2016, 8:30 p.m.

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Spencer, Virginia A; Xu, Ren & Bissell, Mina. Gene Expression in the Third Dimension: The ECM-nucleus Connection, article, October 1, 2009; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc835047/: accessed December 18, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.