Deciphering the details of RNA aminoglycoside interactions: from atomistic models to biotechnological applications Page: 4 of 222
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iii
Specific Exam ples of Riboswitches ....................................................................... 38
Engineered Riboswitches ....................................................................................... 40
Future Perspectives................................................................................................ 42
IMAGING TECHNOLOGIES AND RNA DETECTION..................................................44
Reporter Genes in Im aging .................................................................................... 45
RNA Detection ....................................................................................................... 48
DRUG DEVELOPM ENT AND RESISTANCE............................................................ 54
Drug Development .....................................................................................................54
Drug Resistance .................................................................................................... 55
Physiological Functions of Efflux Pum ps ............................................................... 60
M ultidrug Resistance in Cancer Therapy............................................................... 61
Inhibitors of Efflux Pum ps ....................................................................................... 66
MECHANISMS OF RESISTANCE TO AMINOGLYCOSIDES .................................. 71
Ribosome Alteration................................................................................................. 71
Decreased Permeability and Active Extrusion........................................................ 72
Inactivation of am inoglycosides .............................................................................. 73
APPROACHES TO PREVENT DRUG RESISTANCE .............................................. 79
Sim ultaneous Use of M ultiple Drugs...................................................................... 79
Reducing Antibiotic Use .......................................................................................... 79
Alternative W ays to Com bat Bacterial Infections.................................................... 80
Bacterial interference .............................................................................................. 80
Bacteriophage Therapy.......................................................................................... 80
Bacterial vaccines ................................................................................................... 81
C a tio n ic p e p tid e s .................................................................................................... . 8 1
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Ilgu, Muslum. Deciphering the details of RNA aminoglycoside interactions: from atomistic models to biotechnological applications, thesis or dissertation, July 23, 2012; Ames, Iowa. (https://digital.library.unt.edu/ark:/67531/metadc834107/m1/4/: accessed April 19, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.