Micro-fluidic (Lab-on the- Chip) PCR Array Cartridge for Biological Screening in a Hand Held Device: FInal Report for CRADA no 264. PNNL-T2-258-RU with CombiMatrix Corp

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The worldwide emergence of both new and old diseases resulting from human expansion and also human and materials mobility has and will continue to place stress on both medical and clinical diagnostics. The classical approach to bioagents detection involves the use of differential metabolic assays to determine species type in the case of most bacteria, or the use of cell culture and electron microscopy to diagnose viruses and some bacteria that are intracellular parasites. The long-term goal in bioagent detection is to develop a hand-held instrument featuring disposable cartridges which contain all the necessary reagents, reaction chambers, waste chambers, and ... continued below

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Rainina, Evguenia I. October 31, 2010.

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The worldwide emergence of both new and old diseases resulting from human expansion and also human and materials mobility has and will continue to place stress on both medical and clinical diagnostics. The classical approach to bioagents detection involves the use of differential metabolic assays to determine species type in the case of most bacteria, or the use of cell culture and electron microscopy to diagnose viruses and some bacteria that are intracellular parasites. The long-term goal in bioagent detection is to develop a hand-held instrument featuring disposable cartridges which contain all the necessary reagents, reaction chambers, waste chambers, and micro-fluidics to extract, concentrate, amplify, and analyze nucleic acids. This GIPP project began development of a sensory platform using nucleic-acid based probes. Although research was not completed, initial findings indicated that an advanced sensing device could theoretically be built on a DNA/RNA-based technology platform.

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  • Report No.: PNNL-19914
  • Grant Number: AC05-76RL01830
  • DOI: 10.2172/1008257 | External Link
  • Office of Scientific & Technical Information Report Number: 1008257
  • Archival Resource Key: ark:/67531/metadc833715

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  • October 31, 2010

Added to The UNT Digital Library

  • May 19, 2016, 3:16 p.m.

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  • Nov. 29, 2016, 8:09 p.m.

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Rainina, Evguenia I. Micro-fluidic (Lab-on the- Chip) PCR Array Cartridge for Biological Screening in a Hand Held Device: FInal Report for CRADA no 264. PNNL-T2-258-RU with CombiMatrix Corp, report, October 31, 2010; Richland, Washington. (digital.library.unt.edu/ark:/67531/metadc833715/: accessed August 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.