CBM.DIAGB.03.10.LLNL.007 Final Report

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The purpose of this project was to construct a system for characterizing the threat potential of genomic sequences, specifically assembled draft genomes. New genomes are characterized by initially comparing them against already-sequenced genomes. If the new genome is determined to be from a high-threat species, detailed (forensic-level) characterization is done based on gene and SNP (Single Nucleotide Polymorphism) data comparisons with all other previously sequenced members of that high-threat species. New genomes are compared against a large set of known virulence and antibiotic-resistance genes and also compared against a large set of vectors that could be used for bacterial genetic ... continued below

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PDF-file: 28 pages; size: 2.9 Mbytes

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Slezak, T & Torres, M March 30, 2011.

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Description

The purpose of this project was to construct a system for characterizing the threat potential of genomic sequences, specifically assembled draft genomes. New genomes are characterized by initially comparing them against already-sequenced genomes. If the new genome is determined to be from a high-threat species, detailed (forensic-level) characterization is done based on gene and SNP (Single Nucleotide Polymorphism) data comparisons with all other previously sequenced members of that high-threat species. New genomes are compared against a large set of known virulence and antibiotic-resistance genes and also compared against a large set of vectors that could be used for bacterial genetic engineering. Together, these analyses provide a comprehensive initial assessment of the most likely phylogenetic placement of a new genome, plus an assessment of the known-gene content and an indication of any possible bacterial genetic engineering utilizing vector-mediated techniques. This provides an initial threat potential summary based on high information content comparisons (e.g., thousands of genes, SNPs, and potential genetic engineering vectors) that can be used to guide subsequent operational response or more detailed laboratory characterization.

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PDF-file: 28 pages; size: 2.9 Mbytes

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  • Report No.: LLNL-TR-478794
  • Grant Number: W-7405-ENG-48
  • DOI: 10.2172/1022152 | External Link
  • Office of Scientific & Technical Information Report Number: 1022152
  • Archival Resource Key: ark:/67531/metadc833444

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • March 30, 2011

Added to The UNT Digital Library

  • May 19, 2016, 3:16 p.m.

Description Last Updated

  • Nov. 22, 2016, 10:05 p.m.

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Slezak, T & Torres, M. CBM.DIAGB.03.10.LLNL.007 Final Report, report, March 30, 2011; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc833444/: accessed June 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.