Modeling Flow Past a Tilted Vena Cava Filter

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Inferior vena cava filters are medical devices used to prevent pulmonary embolism (PE) from deep vein thrombosis. In particular, retrievable filters are well-suited for patients who are unresponsive to anticoagulation therapy and whose risk of PE decreased with time. The goal of this work is to use computational fluid dynamics to evaluate the flow past an unoccluded and partially occluded Celect inferior vena cava filter. In particular, the hemodynamic response to thrombus volume and filter tilt is examined, and the results are compared with flow conditions that are known to be thrombogenic. A computer model of the filter inside a ... continued below

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Singer, M A & Wang, S L June 29, 2009.

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Description

Inferior vena cava filters are medical devices used to prevent pulmonary embolism (PE) from deep vein thrombosis. In particular, retrievable filters are well-suited for patients who are unresponsive to anticoagulation therapy and whose risk of PE decreased with time. The goal of this work is to use computational fluid dynamics to evaluate the flow past an unoccluded and partially occluded Celect inferior vena cava filter. In particular, the hemodynamic response to thrombus volume and filter tilt is examined, and the results are compared with flow conditions that are known to be thrombogenic. A computer model of the filter inside a model vena cava is constructed using high resolution digital photographs and methods of computer aided design. The models are parameterized using the Overture software framework, and a collection of overlapping grids is constructed to discretize the flow domain. The incompressible Navier-Stokes equations are solved, and the characteristics of the flow (i.e., velocity contours and wall shear stresses) are computed. The volume of stagnant and recirculating flow increases with thrombus volume. In addition, as the filter increases tilt, the cava wall adjacent to the tilted filter is subjected to low velocity flow that gives rise to regions of low wall shear stress. The results demonstrate the ease of IVC filter modeling with the Overture software framework. Flow conditions caused by the tilted Celect filter may elevate the risk of intrafilter thrombosis and facilitate vascular remodeling. This latter condition also increases the risk of penetration and potential incorporation of the hook of the filter into the vena caval wall, thereby complicating filter retrieval. Consequently, severe tilt at the time of filter deployment may warrant early clinical intervention.

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PDF-file: 21 pages; size: 4.7 Mbytes

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  • Journal Name: Journal of Medical Devices, n/a, n/a, July 1, 2009, n/a

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  • Report No.: LLNL-JRNL-414365
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 1010401
  • Archival Resource Key: ark:/67531/metadc833437

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  • June 29, 2009

Added to The UNT Digital Library

  • May 19, 2016, 3:16 p.m.

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  • Nov. 29, 2016, 8:21 p.m.

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Singer, M A & Wang, S L. Modeling Flow Past a Tilted Vena Cava Filter, article, June 29, 2009; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc833437/: accessed September 21, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.