BEST: Biochemical Engineering Simulation Technology Page: 3 of 23

Table of Contents
Page
A b stra ct .. .... .... .... .... ....... ........ ....... ....... ........ ..... .... .... .. . 1
Introduction ........................................ ............................ 2
Origins of BEST ................................................................ 3
Description of the BEST Simulator ...................................... ........ 4
Kinetics ................................................................. 4
Reactors .................................... ......................... 4
Details of the BEST Models and Methods ....................................... ... 5
Biochemical Kinetics ....................................................... 5
Other Factors Associated with Growth Rate ..................................... 7
Product Formation Rate Expression ....................................... ... 8
Substrate Consumption Rate Expressions ....................................... 8
Batch and Fed-Batch Fermentation Reactor Model .............................. . 9
Continuous Stirred Tank Reactor Model ........................................ 10
Reactor Geometry and Aeration and Heat Transfer Calculations ..................... . 10
Oxygen Transfer and Agitator Power .......................................... 11
Reactor Heat Transfer ...................................................... 12
For the Jacket ............................................................. 12
ASPEN/SP-BEST Examples ................................................ 14
Su m m ary ........................................ .............................. 16
AspenTech's Bioprocess Simulator (BPS) ....................................... ... . 16
ASPEN PLUS BPS Overview ............................................... 16
CSTERILE- Continuous Sterilizer ........................................... 17
BFERM- Batch and Fed-Batch Fermentor ..................................... 17
CFERM- Continuous Fermentor ............................................ 17
Comparison of ASPEN/SP-BEST and the ASPEN PLUS BPS Systems ............... . 17
O ther M odels ............................................................. 19
Summary of ASPEN/SP-BEST and ASPEN PLUS BPS Comparison .................... 20
R eferen ces ...................................................................... 20

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BEST: Biochemical Engineering Simulation Technology, report, January 1, 1996; Golden, Colorado. (digital.library.unt.edu/ark:/67531/metadc832807/m1/3/ocr/: accessed September 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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