Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

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Apoptosis (programmed cell death) plays a major role in development and tissue regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or collagen, was shown to suppress apoptosis of mammary epithelial cells in tissue culture and in vivo. Apoptosis was induced by antibodies to beta 1 integrins or by overexpression of stromelysin-1, which degrades ECM. Expression of interleukin-1 beta converting enzyme (ICE) correlated with the loss of ECM, and inhibitors of ICE activity prevented apoptosis. These results suggest that ECM regulates apoptosis in mammary epithelial cells through an integrin-dependent negative regulation of ICE expression.

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Boudreau, Nancy; Sympson, C. J.; Werb, Zena & Bissell, Mina J. December 1, 1994.

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This article is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 13 times . More information about this article can be viewed below.

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Apoptosis (programmed cell death) plays a major role in development and tissue regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or collagen, was shown to suppress apoptosis of mammary epithelial cells in tissue culture and in vivo. Apoptosis was induced by antibodies to beta 1 integrins or by overexpression of stromelysin-1, which degrades ECM. Expression of interleukin-1 beta converting enzyme (ICE) correlated with the loss of ECM, and inhibitors of ICE activity prevented apoptosis. These results suggest that ECM regulates apoptosis in mammary epithelial cells through an integrin-dependent negative regulation of ICE expression.

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  • Journal Name: Science; Journal Volume: 267; Journal Issue: 5199

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  • Report No.: LBNL-4333E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: CA 57621, DE-AC-03-76-SF00098, DE-AC-03-76-SF10102
  • Office of Scientific & Technical Information Report Number: 1009838
  • Archival Resource Key: ark:/67531/metadc831679

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • December 1, 1994

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  • May 19, 2016, 3:16 p.m.

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  • June 16, 2016, 5:08 p.m.

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Boudreau, Nancy; Sympson, C. J.; Werb, Zena & Bissell, Mina J. Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix, article, December 1, 1994; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc831679/: accessed October 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.