Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs

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Description

Combining contemporary cytogenetic methods with DNA CGH microarray technology and chromosome flow-sorting increases substantially the ability to resolve exchange breakpoints associated with interstitial deletions and translocations, allowing the consequences of radiation damage to be directly measured at low doses, while also providing valuable insights into molecular mechanisms of misrepair processes that, in turn, identify appropriate biophysical models of risk at low doses. Specific aims apply to cells recovered from 3D tissue constructs of human skin and, for the purpose of comparison, the same cells irradiated in traditional 2D cultures. The project includes research complementary to NASA/HRP space radiation project.

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0.756 MB

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Cornforth, Michael March 26, 2012.

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Combining contemporary cytogenetic methods with DNA CGH microarray technology and chromosome flow-sorting increases substantially the ability to resolve exchange breakpoints associated with interstitial deletions and translocations, allowing the consequences of radiation damage to be directly measured at low doses, while also providing valuable insights into molecular mechanisms of misrepair processes that, in turn, identify appropriate biophysical models of risk at low doses. Specific aims apply to cells recovered from 3D tissue constructs of human skin and, for the purpose of comparison, the same cells irradiated in traditional 2D cultures. The project includes research complementary to NASA/HRP space radiation project.

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0.756 MB

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  • Report No.: DOEER64347
  • Grant Number: FG02-07ER64347
  • DOI: 10.2172/1037011 | External Link
  • Office of Scientific & Technical Information Report Number: 1037011
  • Archival Resource Key: ark:/67531/metadc831590

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Creation Date

  • March 26, 2012

Added to The UNT Digital Library

  • May 19, 2016, 3:16 p.m.

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  • June 15, 2016, 12:40 p.m.

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Cornforth, Michael. Heritable Genetic Changes in Cells Recovered From Irradiated 3D Tissue Constructs, report, March 26, 2012; United States. (digital.library.unt.edu/ark:/67531/metadc831590/: accessed December 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.