Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus

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Ascorbic acid, at nontoxic concentrations, causes a substantial reduction in the ability of avian tumor viruses to replicate in both primary avian tendon cells and chicken embryo fibroblasts. The virus-infected cultures appear to be less transformed in the presence of ascorbic acid by the criteria of morphology, reduced glucose uptake, and increased collagen synthesis. The vitamin does not act by altering the susceptibility of the cells to initial infection and transformation, but instead appears to interfere with the spread of infection through a reduction in virus replication and virus infectivity. The effect is reversible and requires the continuous presence of ... continued below

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2711

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BISSELL, MINA J; HATIE, CARROLL; FARSON, DEBORAH A.; SCHWARZ, RICHARD I. & SOO, WHAI-JEN April 1, 1980.

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Description

Ascorbic acid, at nontoxic concentrations, causes a substantial reduction in the ability of avian tumor viruses to replicate in both primary avian tendon cells and chicken embryo fibroblasts. The virus-infected cultures appear to be less transformed in the presence of ascorbic acid by the criteria of morphology, reduced glucose uptake, and increased collagen synthesis. The vitamin does not act by altering the susceptibility of the cells to initial infection and transformation, but instead appears to interfere with the spread of infection through a reduction in virus replication and virus infectivity. The effect is reversible and requires the continuous presence of the vitamin in the culture medium.

Physical Description

2711

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  • Journal Name: Proceedings of the National Academy of Science; Journal Volume: 77; Journal Issue: 5; Related Information: Journal Publication Date: 5/1/1980

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  • Report No.: LBNL-4327E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: IF32 CA 05807-01,
  • DOI: 10.1073/pnas.77.5.2711 | External Link
  • Office of Scientific & Technical Information Report Number: 1008328
  • Archival Resource Key: ark:/67531/metadc830605

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • April 1, 1980

Added to The UNT Digital Library

  • May 19, 2016, 3:16 p.m.

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  • June 15, 2016, 10:04 p.m.

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BISSELL, MINA J; HATIE, CARROLL; FARSON, DEBORAH A.; SCHWARZ, RICHARD I. & SOO, WHAI-JEN. Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus, article, April 1, 1980; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc830605/: accessed October 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.