Involvement of extracellular matrix constituents in breast cancer

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It has recently been established that the extracellular matrix is required for normal functional differentiation of mammary epithelia not only in culture, but also in vivo. The mechanisms by which extracellular matrix affects differentiation, as well as the nature of extracellular matrix constituents which have major impacts on mammary gland function, have only now begun to be dissected. The intricate variety of extracellular matrix-mediated events and the remarkable degree of plasticity of extracellular matrix structure and composition at virtually all times during ontogeny, make such studies difficult. Similarly, during carcinogenesis, the extracellular matrix undergoes gross alterations, the consequences of which ... continued below

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Lochter, Andre & Bissell, Mina J June 1, 1995.

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It has recently been established that the extracellular matrix is required for normal functional differentiation of mammary epithelia not only in culture, but also in vivo. The mechanisms by which extracellular matrix affects differentiation, as well as the nature of extracellular matrix constituents which have major impacts on mammary gland function, have only now begun to be dissected. The intricate variety of extracellular matrix-mediated events and the remarkable degree of plasticity of extracellular matrix structure and composition at virtually all times during ontogeny, make such studies difficult. Similarly, during carcinogenesis, the extracellular matrix undergoes gross alterations, the consequences of which are not yet precisely understood. Nevertheless, an increasing amount of data suggests that the extracellular matrix and extracellular matrix-receptors might participate in the control of most, if not all, of the successive stages of breast tumors, from appearance to progression and metastasis.

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  • Journal Name: Seminars in Cancer Biology; Journal Volume: 6; Journal Issue: 3; Related Information: Journal Publication Date: 6/1/1995

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  • Report No.: LBNL-4097E
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: DE-ACO3-76-SF01012, DE-ACO3-76-SF00098, NCICA 57621
  • DOI: 10.1006/scbi.1995.0017 | External Link
  • Office of Scientific & Technical Information Report Number: 1000964
  • Archival Resource Key: ark:/67531/metadc829821

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • June 1, 1995

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  • May 19, 2016, 3:16 p.m.

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  • June 16, 2016, 12:41 p.m.

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Lochter, Andre & Bissell, Mina J. Involvement of extracellular matrix constituents in breast cancer, article, June 1, 1995; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc829821/: accessed June 24, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.