Low Prevalence of Chronic Beryllium Disease among Workers at a Nuclear Weapons Research and Development Facility

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To study the prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) in a cohort of workers from a nuclear weapons research and development facility. We evaluated 50 workers with BeS with medical and occupational histories, physical examination, chest imaging with HRCT (N=49), and pulmonary function testing. Forty of these workers also underwent bronchoscopy for bronchoalveolar lavage (BAL) and transbronchial biopsies. The mean duration of employment at the facility was 18 yrs and the mean latency (from first possible exposure) to time of evaluation was 32 yrs. Five of the workers had CBD at the time of evaluation (based ... continued below

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PDF-file: 21 pages; size: 0.7 Mbytes

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Arjomandi, M; Seward, J P; Gotway, M B; Nishimura, S; Fulton, G P; Thundiyil, J et al. January 11, 2010.

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Description

To study the prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) in a cohort of workers from a nuclear weapons research and development facility. We evaluated 50 workers with BeS with medical and occupational histories, physical examination, chest imaging with HRCT (N=49), and pulmonary function testing. Forty of these workers also underwent bronchoscopy for bronchoalveolar lavage (BAL) and transbronchial biopsies. The mean duration of employment at the facility was 18 yrs and the mean latency (from first possible exposure) to time of evaluation was 32 yrs. Five of the workers had CBD at the time of evaluation (based on histology or HRCT); three others had evidence of probable CBD. These workers with BeS, characterized by a long duration of potential Be exposure and a long latency, had a low prevalence of CBD.

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PDF-file: 21 pages; size: 0.7 Mbytes

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  • Journal Name: Journal of Occupational and Environmental Medicine, vol. 52, no. 6, June 1, 2010, pp. 647-652; Journal Volume: 52; Journal Issue: 6

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  • Report No.: LLNL-JRNL-422263
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 1020321
  • Archival Resource Key: ark:/67531/metadc829368

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • January 11, 2010

Added to The UNT Digital Library

  • May 19, 2016, 3:16 p.m.

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  • Dec. 6, 2016, 12:40 p.m.

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Arjomandi, M; Seward, J P; Gotway, M B; Nishimura, S; Fulton, G P; Thundiyil, J et al. Low Prevalence of Chronic Beryllium Disease among Workers at a Nuclear Weapons Research and Development Facility, article, January 11, 2010; Livermore, California. (digital.library.unt.edu/ark:/67531/metadc829368/: accessed December 18, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.