FINAL SUMMARIZING REPORT on Grant DE-SC0001014 "Separation of Highly Complex Mixtures by Two-dimension Liquid Chromatography"

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The goal of our research was a fundamental investigation of methods available for the coupling of two separate chromatographic separations that would considerably enhance the individual separation power of each of these two separations. This gain arises from the combination of two independent retention mechanisms, one of them separating the components that coelute on the other column, making possible the separation of many more compounds in a given time. The two separation mechanisms used must be very different. This is possible because many retention mechanisms are available, using different kinds of molecular interactions, hydrophobic or hydrophilic interactions, polar interactions, hydrogen ... continued below

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Guiochon, Georges September 16, 2013.

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The goal of our research was a fundamental investigation of methods available for the coupling of two separate chromatographic separations that would considerably enhance the individual separation power of each of these two separations. This gain arises from the combination of two independent retention mechanisms, one of them separating the components that coelute on the other column, making possible the separation of many more compounds in a given time. The two separation mechanisms used must be very different. This is possible because many retention mechanisms are available, using different kinds of molecular interactions, hydrophobic or hydrophilic interactions, polar interactions, hydrogen bonding, complex formation, ionic interactions, steric exclusion. Two methods can be used, allowing separations to be performed in space (spreading the bands of sample components on a plate covered with stationary phase layer) or in time (eluting the sample components through a column and detecting the bands leaving the column). Both offer a wide variety of possible combinations and were studied.

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  • Report No.: SC0001014-final
  • Grant Number: SC0001014
  • DOI: 10.2172/1092986 | External Link
  • Office of Scientific & Technical Information Report Number: 1092986
  • Archival Resource Key: ark:/67531/metadc827453

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  • September 16, 2013

Added to The UNT Digital Library

  • May 19, 2016, 9:45 a.m.

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  • Dec. 7, 2016, 11:43 a.m.

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Guiochon, Georges. FINAL SUMMARIZING REPORT on Grant DE-SC0001014 "Separation of Highly Complex Mixtures by Two-dimension Liquid Chromatography", report, September 16, 2013; United States. (digital.library.unt.edu/ark:/67531/metadc827453/: accessed June 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.