The Role of Cysteinyl Leukotriene Receptor 2 in Thrombocyte Aggregation

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Cysteinyl leukotriene receptor 2, a G-protein coupled receptor known to be expressed and functional on human platelets. However, it seems that upon ligand activation the cysteinyl leukotriene receptor 2 activates a variety of signaling pathways in multiple cell types among different species. Previously, a former laboratory member Vrinda Kulkarni found cysteinyl leukotriene receptor 2 to be expressed on the surface of adult zebrafish thrombocytes. In this work I studied the characteristics of aggregation in adult zebrafish thrombocytes with the knockdown of cysteinyl leukotriene receptor 2. I used a newly developed knockdown method to study the function of cysteinyl leukotriene receptor ... continued below

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iv, 32 pages : illustrations (chiefly color)

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Reyna, Julianna December 2015.

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This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by UNT Libraries to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 47 times , with 5 in the last month . More information about this thesis can be viewed below.

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  • Reyna, Julianna

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Cysteinyl leukotriene receptor 2, a G-protein coupled receptor known to be expressed and functional on human platelets. However, it seems that upon ligand activation the cysteinyl leukotriene receptor 2 activates a variety of signaling pathways in multiple cell types among different species. Previously, a former laboratory member Vrinda Kulkarni found cysteinyl leukotriene receptor 2 to be expressed on the surface of adult zebrafish thrombocytes. In this work I studied the characteristics of aggregation in adult zebrafish thrombocytes with the knockdown of cysteinyl leukotriene receptor 2. I used a newly developed knockdown method to study the function of cysteinyl leukotriene receptor 2. Knockdown of the cysteinyl leukotriene was confirmed using RT-PCR results showed p=.001, reduced sell surface level of expression of the cysteinyl leukotriene receptor 2 results showed that p=.002. I found that the knockdown of cysteinyl leukotriene receptor 2 results in prothrombotic thrombocytes by using flow cytometry p=.0001.

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iv, 32 pages : illustrations (chiefly color)

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UNT Theses and Dissertations

Theses and dissertations represent a wealth of scholarly and artistic content created by masters and doctoral students in the degree-seeking process. Some ETDs in this collection are restricted to use by the UNT community.

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  • December 2015

Added to The UNT Digital Library

  • March 20, 2016, 10:34 a.m.

Description Last Updated

  • May 25, 2017, 6:08 a.m.

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Citations, Rights, Re-Use

Reyna, Julianna. The Role of Cysteinyl Leukotriene Receptor 2 in Thrombocyte Aggregation, thesis, December 2015; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc822817/: accessed December 10, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .