Examination of Sexual Differences in the Acute Effects of Haloperidol on Licking

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Schizophrenia is a debilitating psychiatric condition affecting almost one percent of the US population. Typical antipsychotics (e.g., haloperidol) have been in use for several decades and are generally very effective in treating the emotional and cognitive effects of schizophrenia, but are used as the last line of treatment due to their severe extrapyramidal motor side effects under chronic exposure. The present study was conducted to investigate the role of sex in determining the oromotor side effects of typical antipsychotics via measuring different behavioral dimensions of male and female Sprague-Dawley rats licking sucrose after haloperidol treatment. The results showed a stronger ... continued below

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iv, 23 pages : illustrations (some color)

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Shoemaker, Danton L. December 2015.

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This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by UNT Libraries to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 24 times . More information about this thesis can be viewed below.

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  • Shoemaker, Danton L.

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Schizophrenia is a debilitating psychiatric condition affecting almost one percent of the US population. Typical antipsychotics (e.g., haloperidol) have been in use for several decades and are generally very effective in treating the emotional and cognitive effects of schizophrenia, but are used as the last line of treatment due to their severe extrapyramidal motor side effects under chronic exposure. The present study was conducted to investigate the role of sex in determining the oromotor side effects of typical antipsychotics via measuring different behavioral dimensions of male and female Sprague-Dawley rats licking sucrose after haloperidol treatment. The results showed a stronger sensitivity in female rats than male rats within total licking responses and inter-lick intervals. The present results suggest closer attention needs to be paid to the role that sexual hormones play in the motor slowing and behavior-reducing effects of antipsychotics.

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iv, 23 pages : illustrations (some color)

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UNT Theses and Dissertations

Theses and dissertations represent a wealth of scholarly and artistic content created by masters and doctoral students in the degree-seeking process. Some ETDs in this collection are restricted to use by the UNT community.

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  • December 2015

Added to The UNT Digital Library

  • March 20, 2016, 10:34 a.m.

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  • May 25, 2017, 8:06 a.m.

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Citations, Rights, Re-Use

Shoemaker, Danton L. Examination of Sexual Differences in the Acute Effects of Haloperidol on Licking, thesis, December 2015; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc822780/: accessed September 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .