Abstract: Although ketamine can induce a state similar to a near-death experience (NDE), there is a striking difference between experiences induced by ketamine used in a recreational context and in an operating room. Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate receptor, as is ibogaine, the main alkaloid of a shrub used in Central Africa to induce NDEs in a religious context. Ibogaine can also elicit different experiences when used in a hallucinatory context or in initiatic rituals, where a superficial state of coma is induced. These data raise the question of whether the chemically-induced NDE-like experience is related to …
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Abstract: Although ketamine can induce a state similar to a near-death experience (NDE), there is a striking difference between experiences induced by ketamine used in a recreational context and in an operating room. Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate receptor, as is ibogaine, the main alkaloid of a shrub used in Central Africa to induce NDEs in a religious context. Ibogaine can also elicit different experiences when used in a hallucinatory context or in initiatic rituals, where a superficial state of coma is induced. These data raise the question of whether the chemically-induced NDE-like experience is related to the use of a particular kind of substance or to a genuine comatose state.
This article is part of the following collection of related materials.
Journal of Near-Death Studies
The Journal of Near-Death Studies is a scholarly peer-reviewed journal devoted to the field of near-death studies. It is published on a quarterly basis by the International Association for Near-Death Studies. The Journal began publication in 1982 under the name Anabiosis which was changed to its current title in 1986 with the start of Volume 6.
Quarterly journal publishing papers related to near-death experiences, including research reports; theoretical or conceptual statements; expressions of a scientific, philosophic, religious, or historical perspective on the study of near-death experiences; cross-cultural studies; individual case histories; and personal accounts of experiences or related phenomena.
Bianchi, Antonio.Comments on "The Ketamine Model of the Near-Death Experience: A Central Role for the N-Methyl-D-Aspartate Receptor",
article,
Autumn 1997;
New York, New York.
(https://digital.library.unt.edu/ark:/67531/metadc798994/:
accessed July 19, 2026),
University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu;
.