Extractive fermentation is a technique that can be used to reduce end-product inhibition by removing fermentation products in situ or in an external recycle loop. A model is presented for fermentation with continuous lactic acid removal by extraction utilizing chemical complexation. The model is formulated considering the kinetics of cell growth and the equilibrium distribution of lactic acid between aqueous and organic phases. Simulations have been carried out for different sets of operating conditions. The choice of pH balances faster kinetics at higher pH against lower product concentrations in the solvent and more difficult regeneration. A key need is for …
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Lawrence Berkeley Lab., CA (United States)
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Extractive fermentation is a technique that can be used to reduce end-product inhibition by removing fermentation products in situ or in an external recycle loop. A model is presented for fermentation with continuous lactic acid removal by extraction utilizing chemical complexation. The model is formulated considering the kinetics of cell growth and the equilibrium distribution of lactic acid between aqueous and organic phases. Simulations have been carried out for different sets of operating conditions. The choice of pH balances faster kinetics at higher pH against lower product concentrations in the solvent and more difficult regeneration. A key need is for liquid extractants or solid sorbents combining stronger uptake ability with economical regeneration and satisfactory biocompatibility.
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Dai, Y. & King, C. J.Modeling of fermentation with continuous lactic acid removal by extraction utilizing reversible chemical complexation,
report,
July 1, 1995;
California.
(https://digital.library.unt.edu/ark:/67531/metadc794288/:
accessed April 17, 2024),
University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu;
crediting UNT Libraries Government Documents Department.