Chloroform and trichloroethylene uptake from water into human skin in vitro: Kinetics and risk implications

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A model recently proposed by the US Environmental Protection Agency (EPA) predicts that short-term dermal uptakes of organic environmental water contaminants are proportional to the square root of exposure time. The model appears to underestimate dermal uptake, based on very limited in vivo uptake data obtained primarily using human subjects. To further assess this model, we examined in vitro dermal uptake kinetics for aqueous organic chemicals using accelerator mass spectrometry (AMS). Specifically, we examined the kinetics of in vitro dermal uptake of {sup 14}C-labeled chloroform and trichloroethylene from dilute (5-ppb) aqueous solutions using full-thickness human cadaver skin exposed for ({le}1 ... continued below

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6 p.

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Bogen, K.T.; Keating, G.A. & Vogel, J.S. March 1, 1995.

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Description

A model recently proposed by the US Environmental Protection Agency (EPA) predicts that short-term dermal uptakes of organic environmental water contaminants are proportional to the square root of exposure time. The model appears to underestimate dermal uptake, based on very limited in vivo uptake data obtained primarily using human subjects. To further assess this model, we examined in vitro dermal uptake kinetics for aqueous organic chemicals using accelerator mass spectrometry (AMS). Specifically, we examined the kinetics of in vitro dermal uptake of {sup 14}C-labeled chloroform and trichloroethylene from dilute (5-ppb) aqueous solutions using full-thickness human cadaver skin exposed for ({le}1 hr).

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6 p.

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INIS; OSTI as DE95014524

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  • Prediction of percutaneous penetration-methods measurements modelling, La Grande Motte (France), Apr 1995

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  • Other: DE95014524
  • Report No.: UCRL-JC--120107
  • Report No.: CONF-9504180--1
  • Grant Number: W-7405-ENG-48
  • Office of Scientific & Technical Information Report Number: 95132
  • Archival Resource Key: ark:/67531/metadc794282

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  • March 1, 1995

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  • Dec. 19, 2015, 7:14 p.m.

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  • Feb. 16, 2016, 3:15 p.m.

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Bogen, K.T.; Keating, G.A. & Vogel, J.S. Chloroform and trichloroethylene uptake from water into human skin in vitro: Kinetics and risk implications, article, March 1, 1995; California. (digital.library.unt.edu/ark:/67531/metadc794282/: accessed September 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.