Characterization of the mammalian DNA polymerase gene(s) and enzyme(s). Annual progress report

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Consistent with the long term goal of our research to understand the nature of the key enzymes in eukaryotic DNA replication we have characterized the properties of the wild type DNA polymerases of the {alpha}-family and their mutants. We have also provided evidence for the role of aphidicolin in the elongation process of the in vivo DNA replication in eukaryotic cells. We also developed a technology for planned prep from a large numbers of clones for direct screening by size or restriction digestion in order to facilitate our goals to clone the DNA polymerase gene.

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5 p.

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Mishra, N.C. January 1, 1994.

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Description

Consistent with the long term goal of our research to understand the nature of the key enzymes in eukaryotic DNA replication we have characterized the properties of the wild type DNA polymerases of the {alpha}-family and their mutants. We have also provided evidence for the role of aphidicolin in the elongation process of the in vivo DNA replication in eukaryotic cells. We also developed a technology for planned prep from a large numbers of clones for direct screening by size or restriction digestion in order to facilitate our goals to clone the DNA polymerase gene.

Physical Description

5 p.

Notes

OSTI as DE95016134

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  • Other Information: PBD: Jan 1994

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  • Other: DE95016134
  • Report No.: DOE/ER/61040--3
  • Grant Number: FG09-90ER61040
  • DOI: 10.2172/89558 | External Link
  • Office of Scientific & Technical Information Report Number: 89558
  • Archival Resource Key: ark:/67531/metadc791650

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Office of Scientific & Technical Information Technical Reports

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  • January 1, 1994

Added to The UNT Digital Library

  • Dec. 19, 2015, 7:14 p.m.

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  • Jan. 4, 2016, 12:09 p.m.

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Mishra, N.C. Characterization of the mammalian DNA polymerase gene(s) and enzyme(s). Annual progress report, report, January 1, 1994; United States. (digital.library.unt.edu/ark:/67531/metadc791650/: accessed January 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.