Expression profiling and comparative sequence derived insights into lipid metabolism

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Description

Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes involved in important processes in lipid metabolism such as sterol efflux, but the utilization of information from these studies has added to our understanding of the regulation of pathways participating in the process. Coupled with these gene expression studies, cross species comparison, searching for sequences conserved through evolution, has proven to be a powerful tool to identify important non-coding regulatory sequences as well as ... continued below

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17 pages

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Callow, Matthew J. & Rubin, Edward M. December 19, 2001.

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Description

Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes involved in important processes in lipid metabolism such as sterol efflux, but the utilization of information from these studies has added to our understanding of the regulation of pathways participating in the process. Coupled with these gene expression studies, cross species comparison, searching for sequences conserved through evolution, has proven to be a powerful tool to identify important non-coding regulatory sequences as well as the discovery of novel genes relevant to lipid biology. An example of the value of this approach was the recent chance discovery of a new apolipoprotein gene (apo AV) that has dramatic effects upon triglyceride metabolism in mice and humans.

Physical Description

17 pages

Notes

OSTI as DE00836785

Source

  • Journal Name: Current Opinion in Lipidology; Journal Volume: 13; Journal Issue: 2; Other Information: Submitted to Current Opinion in Lipidology: Volume 13, No.2; Journal Publication Date: 4/2002

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  • Report No.: LBNL-49387
  • Grant Number: AC03-76SF00098
  • Office of Scientific & Technical Information Report Number: 836785
  • Grant Number: HL63897-02
  • Grant Number: 5U01 HL688881-02
  • Archival Resource Key: ark:/67531/metadc787992

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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  • December 19, 2001

Added to The UNT Digital Library

  • Dec. 3, 2015, 9:30 a.m.

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  • June 22, 2016, 3:40 p.m.

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Callow, Matthew J. & Rubin, Edward M. Expression profiling and comparative sequence derived insights into lipid metabolism, article, December 19, 2001; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc787992/: accessed November 21, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.