Zeste maintains repression of Ubx transgenes: Support for a new model of polycomb repression

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During late embryogenesis, the expression domains of homeotic genes are maintained by two groups of ubiquitously expressed regulators: the Polycomb repressors and the Trithorax activators. It is not known how the activities of the two maintenance systems are initially targeted to the correct genes. Zeste and GAGA are sequence specific DNA binding proteins previously shown to be Trithorax group activators of the homeotic gene Ultrabithorax (Ubx). Here we demonstrate that Zeste and GAGA DNA binding sites at the proximal promoter are also required to maintain, but not to initiate, repression of Ubx. Further, the repression mediated by Zeste DNA binding ... continued below

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21 pages

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Hur, Man-Wook; Laney, Jeffrey D.; Jeon, Sang-Hack; Ali, Janann & Biggin, Mark D. September 1, 2001.

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Description

During late embryogenesis, the expression domains of homeotic genes are maintained by two groups of ubiquitously expressed regulators: the Polycomb repressors and the Trithorax activators. It is not known how the activities of the two maintenance systems are initially targeted to the correct genes. Zeste and GAGA are sequence specific DNA binding proteins previously shown to be Trithorax group activators of the homeotic gene Ultrabithorax (Ubx). Here we demonstrate that Zeste and GAGA DNA binding sites at the proximal promoter are also required to maintain, but not to initiate, repression of Ubx. Further, the repression mediated by Zeste DNA binding site is abolished in zeste null embryos. These data imply that Zeste and probably GAGA mediate Polycomb repression. We present a model in which the dual transcriptional activities of Zeste and GAGA are an essential component of the mechanism that chooses which maintenance system is to be targeted to a given promoter.

Physical Description

21 pages

Notes

OSTI as DE00835803

National Science Foundation Grant R01-GM56803

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  • Journal Name: Development; Journal Volume: 129; Journal Issue: 6; Other Information: Submitted to Development: Volume 129, No.6; Journal Publication Date: 03/2002

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  • Report No.: LBNL-47450
  • Grant Number: AC03-76SF00098
  • Office of Scientific & Technical Information Report Number: 835803
  • Grant Number: R01-GM56803
  • Archival Resource Key: ark:/67531/metadc786941

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  • September 1, 2001

Added to The UNT Digital Library

  • Dec. 3, 2015, 9:30 a.m.

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  • April 4, 2016, 5:48 p.m.

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Hur, Man-Wook; Laney, Jeffrey D.; Jeon, Sang-Hack; Ali, Janann & Biggin, Mark D. Zeste maintains repression of Ubx transgenes: Support for a new model of polycomb repression, article, September 1, 2001; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc786941/: accessed May 24, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.