Human Genetic Marker for Resistance to Radiations and Chemicals

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Description

The major objective of this project is to understand the genetic basis for resistance of humans to radiations and chemicals. In the fission yeast S. pombe, a gene called rad9 plays a key role in promoting resistance to DNA damaging agents and controlling cell cycle progression after radiation or chemical exposure. This investigation focuses on the characterization of a human homologue of this yeast gene, called HRAD9, with the longterm goal of developing the gene as a genetic marker to predict inherent susceptibility to the deleterious health effects caused by DNA damage. The aims concern a molecular characterization of HRAD9 ... continued below

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Lieberman, Howard B. June 1, 2000.

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This report is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. More information about this report can be viewed below.

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Description

The major objective of this project is to understand the genetic basis for resistance of humans to radiations and chemicals. In the fission yeast S. pombe, a gene called rad9 plays a key role in promoting resistance to DNA damaging agents and controlling cell cycle progression after radiation or chemical exposure. This investigation focuses on the characterization of a human homologue of this yeast gene, called HRAD9, with the longterm goal of developing the gene as a genetic marker to predict inherent susceptibility to the deleterious health effects caused by DNA damage. The aims concern a molecular characterization of HRAD9 and determination of its role in mediating the cellular response to radiations and chemicals, as well as its potential role in carcinogenesis.

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  • Other Information: PBD: 1 Jun 2000

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  • Report No.: EMSP-55100--2000
  • Grant Number: FG07-96ER62309
  • DOI: 10.2172/827399 | External Link
  • Office of Scientific & Technical Information Report Number: 827399
  • Archival Resource Key: ark:/67531/metadc786828

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Creation Date

  • June 1, 2000

Added to The UNT Digital Library

  • Dec. 3, 2015, 9:30 a.m.

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  • April 21, 2016, 2:11 p.m.

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Lieberman, Howard B. Human Genetic Marker for Resistance to Radiations and Chemicals, report, June 1, 2000; United States. (digital.library.unt.edu/ark:/67531/metadc786828/: accessed August 18, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.