In situ quantification of genomic instability in breast cancer progression

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Genomic instability is a hallmark of breast and other solid cancers. Presumably caused by critical telomere reduction, GI is responsible for providing the genetic diversity required in the multi-step progression of the disease. We have used multicolor fluorescence in situ hybridization and 3D image analysis to quantify genomic instability cell-by-cell in thick, intact tissue sections of normal breast epithelium, preneoplastic lesions (usual ductal hyperplasia), ductal carcinona is situ or invasive carcinoma of the breast. Our in situ-cell by cell-analysis of genomic instability shows an important increase of genomic instability in the transition from hyperplasia to in situ carcinoma, followed by ... continued below

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Ortiz de Solorzano, Carlos; Chin, Koei; Gray, Joe W. & Lockett, Stephen J. May 15, 2003.

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Genomic instability is a hallmark of breast and other solid cancers. Presumably caused by critical telomere reduction, GI is responsible for providing the genetic diversity required in the multi-step progression of the disease. We have used multicolor fluorescence in situ hybridization and 3D image analysis to quantify genomic instability cell-by-cell in thick, intact tissue sections of normal breast epithelium, preneoplastic lesions (usual ductal hyperplasia), ductal carcinona is situ or invasive carcinoma of the breast. Our in situ-cell by cell-analysis of genomic instability shows an important increase of genomic instability in the transition from hyperplasia to in situ carcinoma, followed by a reduction of instability in invasive carcinoma. This pattern suggests that the transition from hyperplasia to in situ carcinoma corresponds to telomere crisis and invasive carcinoma is a consequence of telomerase reactivation afertelomere crisis.

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OSTI as DE00823070

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  • 25th annual international conference of the IEEE engineering in medicine and biology society, Cancun (MX), 09/17/2003--09/21/2003

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  • Report No.: LBNL--52688
  • Grant Number: AC03-76SF00098
  • Office of Scientific & Technical Information Report Number: 823070
  • Archival Resource Key: ark:/67531/metadc786131

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  • May 15, 2003

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  • Dec. 3, 2015, 9:30 a.m.

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  • April 4, 2016, 3:21 p.m.

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Ortiz de Solorzano, Carlos; Chin, Koei; Gray, Joe W. & Lockett, Stephen J. In situ quantification of genomic instability in breast cancer progression, article, May 15, 2003; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc786131/: accessed August 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.