Electrophoretic and structural studies of DNA-directed Au nanoparticle groupings Page: 2 of 23
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Abstract
Discrete Au nanoparticle/DNA conjugates have been isolated by electrophoresis and used to form small
groupings of particles, such as dimers and trimers. The use of purified conjugates leads to a higher
yield of the target structure, and it has allowed us better control and understanding of the system.
Newly accessible questions, such as the electrophoretic mobility of nanoparticle/DNA hybrids and the
critical role of particle surface charge on mobility have been studied. Detailed characterization by
Transmission Electron Microscopy (TEM) has now been done due to the higher quality of the samples.
A computer program to generate pair distribution functions from TEM images was developed, pointing
out the dependence of interparticle distance with DNA length on dimers of particles.2
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Zanchet, Daniela; Micheel, Christine M.; Parak, Wolfgang J.; Gerion, Daniele; Williams, Shara C. & Alivisatos, A. Paul. Electrophoretic and structural studies of DNA-directed Au nanoparticle groupings, article, August 19, 2002; Berkeley, California. (https://digital.library.unt.edu/ark:/67531/metadc782676/m1/2/: accessed April 24, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.