DOE-FG02-00ER62797 Final Report

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Specific Aims The overall goal of this proposal has been to develop and interface a new technology, molecular gates, with microfabricated systems to add an important capability to microfabricated DNA measurement systems. This project specifically focused on demonstrating how molecular gates could be used to capture a single analyte band, among a stream of bands from a separation or a flow injection analysis experiment, and release it for later measurement, thus allowing further manipulations on the selected analyte. Since the original proposal, the molecular gate concept has been greatly expanded to allow the gates to be used as externally controllable ... continued below

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306KB pages

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Sweedler, J.V. December 1, 2004.

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Description

Specific Aims The overall goal of this proposal has been to develop and interface a new technology, molecular gates, with microfabricated systems to add an important capability to microfabricated DNA measurement systems. This project specifically focused on demonstrating how molecular gates could be used to capture a single analyte band, among a stream of bands from a separation or a flow injection analysis experiment, and release it for later measurement, thus allowing further manipulations on the selected analyte. Since the original proposal, the molecular gate concept has been greatly expanded to allow the gates to be used as externally controllable intelligent interconnects in multilayer microfluidic networks. We have demonstrated: (1) the ability of the molecular gates to work with a much wider range of biological molecules including DNA, proteins and small metabolites; and (2) the capability of performing an electrophoretic separation and sequestering individual picoliter volume components (or even classes of components) into separate channels for further analysis. Both capabilities will enable characterization of small mass amounts of complex mixtures of DNA, proteins and even small molecules--allowing them to be further separated and chemically characterized.

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306KB pages

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OSTI as DE00835220

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  • Other Information: PBD: 1 Dec 2004

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  • Report No.: DOE/ER/62797-6
  • Grant Number: FG02-99ER62797
  • DOI: 10.2172/835220 | External Link
  • Office of Scientific & Technical Information Report Number: 835220
  • Archival Resource Key: ark:/67531/metadc781979

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • December 1, 2004

Added to The UNT Digital Library

  • Dec. 3, 2015, 9:30 a.m.

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  • June 10, 2016, 5:56 p.m.

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Sweedler, J.V. DOE-FG02-00ER62797 Final Report, report, December 1, 2004; United States. (digital.library.unt.edu/ark:/67531/metadc781979/: accessed November 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.