Radiation Leukemogenesis: Applying Basic Science of Epidemiological Estimates of Low Dose Risks and Dose-Rate Effects Metadata

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Title

  • Main Title Radiation Leukemogenesis: Applying Basic Science of Epidemiological Estimates of Low Dose Risks and Dose-Rate Effects

Creator

  • Author: Hoel, D. G.
    Creator Type: Personal

Contributor

  • Sponsor: United States. Department of Energy. Office of Energy Research.
    Contributor Type: Organization
    Contributor Info: USDOE Office of Energy Research (ER) (United States)

Publisher

  • Name: Medical University of South Carolina (United States)
    Place of Publication: United States

Date

  • Creation: 1998-11-01

Language

  • English

Description

  • Content Description: The next stage of work has been to examine more closely the A-bomb leukemia data which provides the underpinnings of the risk estimation of CML in the above mentioned manuscript. The paper by Hoel and Li (Health Physics 75:241-50) shows how the linear-quadratic model has basic non-linearities at the low dose region for the leukemias including CML. Pierce et. al., (Radiation Research 123:275-84) have developed distributions for the uncertainty in the estimated exposures of the A-bomb cohort. Kellerer, et. al., (Radiation and Environmental Biophysics 36:73-83) has further considered possible errors in the estimated neutron values and with changing RBE values with dose and has hypothesized that the tumor response due to gamma may not be linear. We have incorporated his neutron model and have constricted new A-bomb doses based on his model adjustments. The Hoel and Li dose response analysis has also been applied using the Kellerer neutron dose adjustments for the leukemias. Finally, both Pierce's dose uncertainties and Kellerer neutron adjustments are combined as well as the varying RBE with dose as suggested by Rossi and Zaider and used for leukemia dose-response analysis. First the results of Hoel and Li showing a significantly improved fit of the linear-quadratic dose response by the inclusion of a threshold (i.e. low-dose nonlinearity) persisted. This work has been complete for both solid tumor as well as leukemia for both mortality as well as incidence data. The results are given in the manuscript described below which has been submitted to Health Physics.
  • Physical Description: 7 pages

Subject

  • Keyword: Radiation Protection
  • Keyword: Neoplasms
  • Keyword: Leukemia
  • Keyword: Biophysics
  • Keyword: Leukemogenesis
  • Keyword: Neutrons
  • Keyword: Physics
  • STI Subject Categories: 72 Physics Of Elementary Particles And Fields
  • Keyword: Radiations
  • Keyword: Mortality

Source

  • Other Information: PBD: 1 Nov 1998

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report

Format

  • Text

Identifier

  • Report No.: DOE/ER/62728-1012258-0003997
  • Grant Number: FG02-99ER62728
  • DOI: 10.2172/826164
  • Office of Scientific & Technical Information Report Number: 826164
  • Archival Resource Key: ark:/67531/metadc781397

Note

  • Display Note: INIS; OSTI as DE00826164