Structural and Functional Studies on Nucleotide Excision Repair From Recognition to Incision.

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Maintenance of the correct genetic information is crucial for all living organisms because mutations are the primary cause of hereditary diseases, as well as cancer and may also be involved in aging. The importance of genomic integrity is underscored by the fact that 80 to 90% of all human cancers are ultimately due to DNA damage. Among the different repair mechanisms that have evolved to protect the genome, nucleotide excision repair (NER) is a universal pathway found in all organisms. NER removes a wide variety of bulky DNA adducts including the carcinogenic cyclobutane pyrimidine dimers induced by UV radiation, benzo(a)pyrene-guanine ... continued below

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Kisker, Caroline January 1, 2001.

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Maintenance of the correct genetic information is crucial for all living organisms because mutations are the primary cause of hereditary diseases, as well as cancer and may also be involved in aging. The importance of genomic integrity is underscored by the fact that 80 to 90% of all human cancers are ultimately due to DNA damage. Among the different repair mechanisms that have evolved to protect the genome, nucleotide excision repair (NER) is a universal pathway found in all organisms. NER removes a wide variety of bulky DNA adducts including the carcinogenic cyclobutane pyrimidine dimers induced by UV radiation, benzo(a)pyrene-guanine adducts caused by smoking and the guanine-cisplatin adducts induced by chemotherapy. The importance of this repair mechanism is reflected by three severe inherited diseases in humans, which are due to defects in NER: xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy.

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  • Report No.: DEFG0201ER63073
  • Grant Number: FG02-01ER63073
  • DOI: 10.2172/860658 | External Link
  • Office of Scientific & Technical Information Report Number: 860658
  • Archival Resource Key: ark:/67531/metadc780579

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  • January 1, 2001

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  • Dec. 3, 2015, 9:30 a.m.

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  • Aug. 3, 2016, 6:03 p.m.

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Kisker, Caroline. Structural and Functional Studies on Nucleotide Excision Repair From Recognition to Incision., report, January 1, 2001; United States. (https://digital.library.unt.edu/ark:/67531/metadc780579/: accessed March 18, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.