Mineralization of Synthetic Polymer Scaffolds: A Bottom-upApproach for the Development of Artificial Bone

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The controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Crosslinked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to template the formation of hydroxyapatite. Strong adhesion between the organic and inorganic materials was achieved for hydrogels functionalized with either carboxylate or hydroxy ligands. The mineral-nucleating potential of hydroxyl groups identified here broadens the design parameters for synthetic bone-like composites and suggests a ... continued below

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Song, Jie; Viengkham, Malathong & Bertozzi, Carolyn R. September 27, 2004.

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The controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Crosslinked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to template the formation of hydroxyapatite. Strong adhesion between the organic and inorganic materials was achieved for hydrogels functionalized with either carboxylate or hydroxy ligands. The mineral-nucleating potential of hydroxyl groups identified here broadens the design parameters for synthetic bone-like composites and suggests a potential role for hydroxylated collagen proteins in bone mineralization.

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  • Journal Name: Journal of American Chemical Society; Journal Volume: 127; Journal Issue: 10; Related Information: Journal Publication Date: 03/16/2005

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  • Report No.: LBNL--56375
  • Grant Number: DE-AC02-05CH11231
  • Grant Number: NIH:DE-AC03-76SF00098
  • Grant Number: NIHR01DE015633-01
  • Office of Scientific & Technical Information Report Number: 861167
  • Archival Resource Key: ark:/67531/metadc780335

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Office of Scientific & Technical Information Technical Reports

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  • September 27, 2004

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  • Dec. 3, 2015, 9:30 a.m.

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  • April 1, 2016, 8:18 p.m.

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Song, Jie; Viengkham, Malathong & Bertozzi, Carolyn R. Mineralization of Synthetic Polymer Scaffolds: A Bottom-upApproach for the Development of Artificial Bone, article, September 27, 2004; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc780335/: accessed November 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.