Analysis of Gene Targeting & Nonhomologous End-joining. Final Report

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Overall, we identified a number of new proteins that participate in nonhomologous end-joining and also in telomere addition to the ends of broken chromosomes. We showed that NHEJ is severely reduced in cells expressing both yeast mating-type genes and then went on to identify the NEJ1 gene that was under this control. We showed the epistasis relations among a set of mutations that impair telomere addition and we showed that there are in fact two pathways to repair broken chromosomes in the absence of telomerase. We characterized the DNA damage checkpoint pathway in response to a single broken chromosome and … continued below

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Haber, J. E. November 30, 2002.

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  • Brandeis University
    Publisher Info: Brandeis University, Waltham, Massachusetts (United States)
    Place of Publication: Waltham, Massachusetts

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Overall, we identified a number of new proteins that participate in nonhomologous end-joining and also in telomere addition to the ends of broken chromosomes. We showed that NHEJ is severely reduced in cells expressing both yeast mating-type genes and then went on to identify the NEJ1 gene that was under this control. We showed the epistasis relations among a set of mutations that impair telomere addition and we showed that there are in fact two pathways to repair broken chromosomes in the absence of telomerase. We characterized the DNA damage checkpoint pathway in response to a single broken chromosome and characterized especially the adaptation of cells arrested by an unrepaired DSB. We demonstrated that the DNA damage response is nuclear-limited. We showed adaptation defects for Tid1and Srs2 proteins and showed that Srs2 was also recovery-defective, even when DNA was repaired.

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OSTI as DE00825003

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  • Other Information: PBD: 30 Nov 2002

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  • November 30, 2002

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  • Dec. 3, 2015, 9:30 a.m.

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Haber, J. E. Analysis of Gene Targeting & Nonhomologous End-joining. Final Report, report, November 30, 2002; Waltham, Massachusetts. (https://digital.library.unt.edu/ark:/67531/metadc780303/: accessed December 13, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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