Proteomic Dissection of the Mitochondrial DNA Metabolism Apparatus in Arabidopsis

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This study involves the investigation of nuclear genetic components that regulate mitochondrial genome behavior in higher plants. The approach utilizes the advanced plant model system of Arabidopsis thaliana to identify and functionally characterize multiple components of the mitochondrial DNA replication, recombination and mismatch repair system and their interaction partners. The rationale for the research stems from the central importance of mitochondria to overall cellular metabolism and the essential nature of the mitochondrial genome to mitochondrial function. Relatively little is understood about mitochondrial DNA maintenance and transmission in higher eukaryotes, and the higher plant mitochondrial genome displays unique properties and behavior. ... continued below

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Mackenzie, SAlly A. January 6, 2004.

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Description

This study involves the investigation of nuclear genetic components that regulate mitochondrial genome behavior in higher plants. The approach utilizes the advanced plant model system of Arabidopsis thaliana to identify and functionally characterize multiple components of the mitochondrial DNA replication, recombination and mismatch repair system and their interaction partners. The rationale for the research stems from the central importance of mitochondria to overall cellular metabolism and the essential nature of the mitochondrial genome to mitochondrial function. Relatively little is understood about mitochondrial DNA maintenance and transmission in higher eukaryotes, and the higher plant mitochondrial genome displays unique properties and behavior. This investigation has revealed at least three important properties of plant mitochondrial DNA metabolism components. (1) Many are dual targeted to mitochondrial and chloroplasts by novel mechanisms, suggesting that the mitochondria a nd chloroplast share their genome maintenance apparatus. (2)The MSH1 gene, originating as a component of mismatch repair, has evolved uniquely in plants to participate in differential replication of the mitochondrial genome. (3) This mitochondrial differential replication process, termed substoichiometric shifting and also involving a RecA-related gene, appears to represent an adaptive mechanism to expand plant reproductive capacity and is likely present throughout the plant kingdom.

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OSTI as DE00835670

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  • Other Information: PBD: 6 Jan 2004

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  • Report No.: NONE
  • Grant Number: FG02-03ER15440
  • DOI: 10.2172/835670 | External Link
  • Office of Scientific & Technical Information Report Number: 835670
  • Archival Resource Key: ark:/67531/metadc779551

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  • January 6, 2004

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  • Dec. 3, 2015, 9:30 a.m.

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  • Aug. 4, 2016, 7:52 p.m.

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Mackenzie, SAlly A. Proteomic Dissection of the Mitochondrial DNA Metabolism Apparatus in Arabidopsis, report, January 6, 2004; United States. (digital.library.unt.edu/ark:/67531/metadc779551/: accessed October 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.