The spectrum of mutation produced by low dose radiation

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Inherited mutations are the basis of evolution and acquired mutations in humans are important in ageing, cancer and possibly various forms of tissue degeneration. Mutations are responsible for many of the long-term effects of radiation. However, sensitive direct detection of mutations in humans has been difficult. The aims of the project were to develop methods for the sensitive enumeration of mutations in DNA, to measure mutation frequencies in a wide variety of tissue types and to quantify the mutational effect of direct oxidative damage produced by radiation, at both high and low doses. The project was successful in developing a ... continued below

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260kb pages

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Morley, Alexander A. & Turner, David R. October 31, 2004.

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Description

Inherited mutations are the basis of evolution and acquired mutations in humans are important in ageing, cancer and possibly various forms of tissue degeneration. Mutations are responsible for many of the long-term effects of radiation. However, sensitive direct detection of mutations in humans has been difficult. The aims of the project were to develop methods for the sensitive enumeration of mutations in DNA, to measure mutation frequencies in a wide variety of tissue types and to quantify the mutational effect of direct oxidative damage produced by radiation, at both high and low doses. The project was successful in developing a sensitive method which could detect mutations directly in the genetic material, DNA at a sensitivity of 1 mutated molecule in 1000000000 unmutated molecules. However a number of methodological problems had to be overcome and lack of ongoing funding made it impossible to fulfill all of the aims of the project

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260kb pages

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  • Other Information: PBD: 31 Oct 2004

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  • Report No.: DOE/ER/62906- Final Report
  • Grant Number: FG02-00ER62906
  • DOI: 10.2172/834002 | External Link
  • Office of Scientific & Technical Information Report Number: 834002
  • Archival Resource Key: ark:/67531/metadc779405

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Office of Scientific & Technical Information Technical Reports

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  • October 31, 2004

Added to The UNT Digital Library

  • Dec. 3, 2015, 9:30 a.m.

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  • June 10, 2016, 6:15 p.m.

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Morley, Alexander A. & Turner, David R. The spectrum of mutation produced by low dose radiation, report, October 31, 2004; United States. (digital.library.unt.edu/ark:/67531/metadc779405/: accessed August 14, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.