Deletion of a coordinate regulator of type 2 cytokine expression in mice

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Mechanisms underlying the differentiation of stable T helper subsets will be important in understanding how discrete types of immunity develop in response to different pathogens. An evolutionarily conserved {approx}400 base pair non-coding sequence in the IL-4/IL-13 intergenic region, designated CNS-1, was deleted in mice. The capacity to develop Th2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1-deleted mice maintained their capacity to produce IL-4. A T cell-specific element critical for optimal expression of type 2 cytokines may represent evolution of a regulatory sequence exploited ... continued below

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Mohrs, Markus; Blankespoor, Catherine M.; Wang, Zhi-En; Loots, Gaby G.; Hadeiba, Husein; Shinkai, Kanade et al. July 30, 2001.

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Mechanisms underlying the differentiation of stable T helper subsets will be important in understanding how discrete types of immunity develop in response to different pathogens. An evolutionarily conserved {approx}400 base pair non-coding sequence in the IL-4/IL-13 intergenic region, designated CNS-1, was deleted in mice. The capacity to develop Th2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1-deleted mice maintained their capacity to produce IL-4. A T cell-specific element critical for optimal expression of type 2 cytokines may represent evolution of a regulatory sequence exploited by adaptive immunity.

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OSTI as DE00836370

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  • Nature Immunology, Volume 2, Issue 9, September 2001

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  • Report No.: LBNL--48789
  • Grant Number: AC03-76SF00098
  • Office of Scientific & Technical Information Report Number: 836370
  • Grant Number: HL56385
  • Grant Number: AI30663
  • Grant Number: HL66671
  • Archival Resource Key: ark:/67531/metadc779064

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Office of Scientific & Technical Information Technical Reports

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  • July 30, 2001

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  • Dec. 3, 2015, 9:30 a.m.

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  • Nov. 30, 2017, 7 p.m.

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Mohrs, Markus; Blankespoor, Catherine M.; Wang, Zhi-En; Loots, Gaby G.; Hadeiba, Husein; Shinkai, Kanade et al. Deletion of a coordinate regulator of type 2 cytokine expression in mice, article, July 30, 2001; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc779064/: accessed December 12, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.