Novel Mass Spectrometry Mutation screening for contaminant Impact Analysis Metadata

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Title

  • Main Title Novel Mass Spectrometry Mutation screening for contaminant Impact Analysis

Creator

  • Author: Chen, Chung Hsuan (Winston)
    Creator Type: Personal

Contributor

  • Sponsor: United States. Department of Energy. Office of Environmental Management.
    Contributor Type: Organization
    Contributor Info: USDOE Office of Environmental Management (EM) (United States)

Publisher

  • Name: Oak Ridge National Laboratory
    Place of Publication: Oak Ridge, Tennessee
    Additional Info: Oak Ridge National Lab., Oak Ridge, TN (United States)

Date

  • Creation: 1999-06-01

Language

  • English

Description

  • Content Description: The objective of this program is to develop innovative mass spectrometry technology to achieve fast mutation screening and to reveal the linkage between gene mutation and contaminants. Mass spectrometry has the potential to achieve very fast speed sample analysis. However, the poor mass resolution and low detection efficiency for long DNAs limit the broad application for mutation analysis. New innovative approaches for improving mass resolution and detection sensitivity will be pursued to help to achieve rapid DNA screening. Allele specific polymerase chain reaction (ASPCR) coupled with mass spectrometry for DNA mutation detection will be pursued. This technology is to be applied to wildlife species such as fish for the genotoxic effect of hazardous waste to be assessed at DNA level.
  • Physical Description: vp.

Subject

  • Keyword: Velocity
  • Keyword: Dna
  • Keyword: Mass Resolution
  • STI Subject Categories: 59 Basic Biological Sciences
  • Keyword: Sensitivity
  • Keyword: Mutations
  • Keyword: Efficiency
  • Keyword: Mass Spectroscopy
  • Keyword: Detection
  • Keyword: Wastes
  • STI Subject Categories: 54 Environmental Sciences
  • Keyword: Gene Mutations
  • Keyword: Polymerase Chain Reaction

Source

  • Other Information: PBD: 1 Jun 1999

Collection

  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI

Institution

  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report

Format

  • Text

Identifier

  • Report No.: EMSP-60218--1999
  • DOI: 10.2172/829891
  • Office of Scientific & Technical Information Report Number: 829891
  • Archival Resource Key: ark:/67531/metadc778221
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