Noise minimization in eukaryotic gene expression

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All organisms have elaborate mechanisms to control rates of protein production. However, protein production is also subject to stochastic fluctuations, or noise. Several recent studies in Saccharomyces cerevisiae and Escherichia coli have investigated the relationship between transcription and translation rates and stochastic fluctuations in protein levels, or more generally, how such randomness is a function of intrinsic and extrinsic factors. However, the fundamental question of whether stochasticity in protein expression is generally biologically relevant has not been addressed, and it remains unknown whether random noise in the protein production rate of most genes significantly affects the fitness of any organism. ... continued below

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Fraser, Hunter B.; Hirsh, Aaron E.; Giaever, Guri; Kumm, Jochen & Eisen, Michael B. January 15, 2004.

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All organisms have elaborate mechanisms to control rates of protein production. However, protein production is also subject to stochastic fluctuations, or noise. Several recent studies in Saccharomyces cerevisiae and Escherichia coli have investigated the relationship between transcription and translation rates and stochastic fluctuations in protein levels, or more generally, how such randomness is a function of intrinsic and extrinsic factors. However, the fundamental question of whether stochasticity in protein expression is generally biologically relevant has not been addressed, and it remains unknown whether random noise in the protein production rate of most genes significantly affects the fitness of any organism. We propose that organisms should be particularly sensitive to variation in the protein levels of two classes of genes: genes whose deletion is lethal to the organism and genes that encode subunits of multiprotein complexes. Using an experimentally verified model of stochastic gene expression in S. cerevisiae, we estimate the noise in protein production for nearly every yeast gene, and confirm our prediction that the production of essential and complex-forming proteins involves lower levels of noise than does the production of most other genes. Our results support the hypothesis that noise in gene expression is a biologically important variable, is generally detrimental to organismal fitness, and is subject to natural selection.

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  • Journal Name: PLOS Biology; Journal Volume: 2; Journal Issue: 6; Other Information: Journal Publication Date: June 2004

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  • Report No.: LBNL--55191
  • Grant Number: AC03-76SF00098
  • DOI: 10.1371/journal.pbio.0020137 | External Link
  • Office of Scientific & Technical Information Report Number: 832962
  • Archival Resource Key: ark:/67531/metadc777098

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  • January 15, 2004

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  • Dec. 3, 2015, 9:30 a.m.

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  • June 22, 2016, 3:57 p.m.

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Fraser, Hunter B.; Hirsh, Aaron E.; Giaever, Guri; Kumm, Jochen & Eisen, Michael B. Noise minimization in eukaryotic gene expression, article, January 15, 2004; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc777098/: accessed August 23, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.