CYP1B1 expression, a potential risk factor for breast cancer

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CYP1B1 expression in non-tumor breast tissue from breast cancer patients and cancer-free individuals was determined to test the hypothesis that high CYP1B1 expression is a risk factor for breast cancer. Large interindividual variations in CYP1B1 expression were found with CYP1B1 levels notably higher in breast cancer patients than cancer-free individuals. The results indicate that CYP1B1 might play a role in breast cancer either through increased PAH activation or through metabolism of endogenous estrogen to a carcinogenic derivative.

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Goth-Goldstein, Regine; Erdmann, Christine A. & Russell, Marion May 31, 2001.

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Description

CYP1B1 expression in non-tumor breast tissue from breast cancer patients and cancer-free individuals was determined to test the hypothesis that high CYP1B1 expression is a risk factor for breast cancer. Large interindividual variations in CYP1B1 expression were found with CYP1B1 levels notably higher in breast cancer patients than cancer-free individuals. The results indicate that CYP1B1 might play a role in breast cancer either through increased PAH activation or through metabolism of endogenous estrogen to a carcinogenic derivative.

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Notes

OSTI as DE00835332

Source

  • Journal Name: Polycyclic Aromatic Compounds; Journal Volume: 23; Journal Issue: 3; Other Information: Submitted to Polycyclic Aromatic Compounds; Volume 23, No.3; Journal Publication Date: 2003

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  • Report No.: LBNL--48024
  • Grant Number: AC03-76SF00098
  • Office of Scientific & Technical Information Report Number: 835332
  • Archival Resource Key: ark:/67531/metadc777004

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  • May 31, 2001

Added to The UNT Digital Library

  • Dec. 3, 2015, 9:30 a.m.

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  • June 22, 2016, 3:36 p.m.

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Goth-Goldstein, Regine; Erdmann, Christine A. & Russell, Marion. CYP1B1 expression, a potential risk factor for breast cancer, article, May 31, 2001; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc777004/: accessed August 21, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.