Development and Evaluation of Rhenium-188-labeled Radioactive Stents for Restenosis Therapy and Development of Strategies for Radiolabeling Brachytherapy Sources with Palladium-103

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Description

This project involved collaboration between InnerDyne, Inc., and radiopharmaceutical research programs at the Oak Ridge National Laboratory (ORNL) and Brookhaven National Laboratory (BNL) which explored new strategies for the development and animal testing of radioactive rhenium-188-labeled implantable stent sources for the treatment of coronary restenosis after angioplasty and the development of chemical species radiolabeled with the palladium-103 radioisotope for the treatment of cancer. Rhenium-188 was made available for these studies from radioactive decay of tungsten-188 produced in the ORNL High Flux Isotope Reactor (HFIR). Stent activation and coating technology was developed and provided by InnerDyne, Inc., and stent radiolabeling technology ... continued below

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10 pages

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Knapp, F.F. April 27, 2001.

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Description

This project involved collaboration between InnerDyne, Inc., and radiopharmaceutical research programs at the Oak Ridge National Laboratory (ORNL) and Brookhaven National Laboratory (BNL) which explored new strategies for the development and animal testing of radioactive rhenium-188-labeled implantable stent sources for the treatment of coronary restenosis after angioplasty and the development of chemical species radiolabeled with the palladium-103 radioisotope for the treatment of cancer. Rhenium-188 was made available for these studies from radioactive decay of tungsten-188 produced in the ORNL High Flux Isotope Reactor (HFIR). Stent activation and coating technology was developed and provided by InnerDyne, Inc., and stent radiolabeling technology and animal studies were conducted by InnerDyne staff in conjunction with investigators at BNL. Collaborative studies in animals were supported at sites by InnerDyne, Inc. New chemical methods for attaching the palladium-103 radioisotope to bifunctional chelate technologies were developed by investigators at ORNL.

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10 pages

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  • Other Information: PBD: 27 Apr 2001

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  • Report No.: C/ORNL98-0502
  • Grant Number: AC05-00OR22725
  • DOI: 10.2172/814392 | External Link
  • Office of Scientific & Technical Information Report Number: 814392
  • Archival Resource Key: ark:/67531/metadc740139

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

Office of Scientific and Technical Information (OSTI) is the Department of Energy (DOE) office that collects, preserves, and disseminates DOE-sponsored research and development (R&D) results that are the outcomes of R&D projects or other funded activities at DOE labs and facilities nationwide and grantees at universities and other institutions.

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Creation Date

  • April 27, 2001

Added to The UNT Digital Library

  • Oct. 18, 2015, 6:40 p.m.

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  • March 31, 2016, 12:50 p.m.

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Knapp, F.F. Development and Evaluation of Rhenium-188-labeled Radioactive Stents for Restenosis Therapy and Development of Strategies for Radiolabeling Brachytherapy Sources with Palladium-103, report, April 27, 2001; United States. (digital.library.unt.edu/ark:/67531/metadc740139/: accessed September 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.