Rapid Ultrasensitive Chemical-Fingerprint Detection of Chemical and Biochemical Warfare Agents

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Description

Vibrational spectra can serve as chemical fingerprints for positive identification of chemical and biological warfare molecules. The required speed and sensitivity might be achieved with surface-enhanced Raman spectroscopy (SERS) using nanotextured metal surfaces. Systematic and reproducible methods for preparing metallic surfaces that maximize sensitivity have not been previously developed. This work sought to develop methods for forming high-efficiency metallic nanostructures that can be integrated with either gas or liquid-phase chem-lab-on-a-chip separation columns to provide a highly sensitive, highly selective microanalytical system for detecting current and future chem/bio agents. In addition, improved protein microchromatographic systems have been made by the creation ... continued below

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39 pages

Creation Information

ASHBY, CAROL I.; SHEPODD, TIMOTHY J.; YELTON, WILLIAM G. & MURON, DAVID J. December 1, 2002.

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This report is part of the collection entitled: Office of Scientific & Technical Information Technical Reports and was provided by UNT Libraries Government Documents Department to Digital Library, a digital repository hosted by the UNT Libraries. More information about this report can be viewed below.

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  • Sandia National Laboratories
    Publisher Info: Sandia National Labs., Albuquerque, NM, and Livermore, CA (United States)
    Place of Publication: Albuquerque, New Mexico

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Description

Vibrational spectra can serve as chemical fingerprints for positive identification of chemical and biological warfare molecules. The required speed and sensitivity might be achieved with surface-enhanced Raman spectroscopy (SERS) using nanotextured metal surfaces. Systematic and reproducible methods for preparing metallic surfaces that maximize sensitivity have not been previously developed. This work sought to develop methods for forming high-efficiency metallic nanostructures that can be integrated with either gas or liquid-phase chem-lab-on-a-chip separation columns to provide a highly sensitive, highly selective microanalytical system for detecting current and future chem/bio agents. In addition, improved protein microchromatographic systems have been made by the creation of acrylate-based porous polymer monoliths that can serve as protein preconcentrators to reduce the optical system sensitivity required to detect and identify a particular protein, such as a bacterial toxin.

Physical Description

39 pages

Source

  • Other Information: PBD: 1 Dec 2002

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  • Report No.: SAND2002-4055
  • Grant Number: AC04-94AL85000
  • DOI: 10.2172/808603 | External Link
  • Office of Scientific & Technical Information Report Number: 808603
  • Archival Resource Key: ark:/67531/metadc739429

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Creation Date

  • December 1, 2002

Added to The UNT Digital Library

  • Oct. 18, 2015, 6:40 p.m.

Description Last Updated

  • April 11, 2016, 8:18 p.m.

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ASHBY, CAROL I.; SHEPODD, TIMOTHY J.; YELTON, WILLIAM G. & MURON, DAVID J. Rapid Ultrasensitive Chemical-Fingerprint Detection of Chemical and Biochemical Warfare Agents, report, December 1, 2002; Albuquerque, New Mexico. (digital.library.unt.edu/ark:/67531/metadc739429/: accessed September 24, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.