Spatiotemporal reconstruction of list-mode PET data

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We describe a method for computing a continuous time estimate of tracer density using list-mode positron emission tomography data. The rate function in each voxel is modeled as an inhomogeneous Poisson process whose rate function can be represented using a cubic B-spline basis. The rate functions are estimated by maximizing the likelihood of the arrival times of detected photon pairs over the control vertices of the spline, modified by quadratic spatial and temporal smoothness penalties and a penalty term to enforce nonnegativity. Randoms rate functions are estimated by assuming independence between the spatial and temporal randoms distributions. Similarly, scatter rate ... continued below

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Nichols, Thomas E.; Qi, Jinyi; Asma, Evren & Leahy, Richard M. March 1, 2002.

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We describe a method for computing a continuous time estimate of tracer density using list-mode positron emission tomography data. The rate function in each voxel is modeled as an inhomogeneous Poisson process whose rate function can be represented using a cubic B-spline basis. The rate functions are estimated by maximizing the likelihood of the arrival times of detected photon pairs over the control vertices of the spline, modified by quadratic spatial and temporal smoothness penalties and a penalty term to enforce nonnegativity. Randoms rate functions are estimated by assuming independence between the spatial and temporal randoms distributions. Similarly, scatter rate functions are estimated by assuming spatiotemporal independence and that the temporal distribution of the scatter is proportional to the temporal distribution of the trues. A quantitative evaluation was performed using simulated data and the method is also demonstrated in a human study using 11C-raclopride.

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  • Journal Name: IEEE Transactions on Medical Imaging; Journal Volume: 21; Journal Issue: 4; Other Information: Journal Publication Date: April 2002

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  • Report No.: LBNL--50361
  • Grant Number: AC03-76SF00098
  • DOI: 10.1109/TMI.2002.1000263 | External Link
  • Office of Scientific & Technical Information Report Number: 815325
  • Archival Resource Key: ark:/67531/metadc739234

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  • March 1, 2002

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  • Oct. 18, 2015, 6:40 p.m.

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  • Oct. 3, 2017, 7:33 p.m.

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Nichols, Thomas E.; Qi, Jinyi; Asma, Evren & Leahy, Richard M. Spatiotemporal reconstruction of list-mode PET data, article, March 1, 2002; Berkeley, California. (digital.library.unt.edu/ark:/67531/metadc739234/: accessed November 22, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.