FEASIBILITY OF POSITRON EMISSION TOMOGRAPHY OF DOSE DISTRIBUTION IN PROTON BEAM CANCER THERAPY.

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Proton therapy is a treatment modality of increasing utility in clinical radiation oncology mostly because its dose distribution conforms more tightly to the target volume than x-ray radiation therapy. One important feature of proton therapy is that it produces a small amount of positron-emitting isotopes along the beam-path through the non-elastic nuclear interaction of protons with target nuclei such as {sup 12}C, {sup 14}N, and {sup 16}O. These radioisotopes, mainly {sup 11}C, {sup 13}N and {sup 15}O, allow imaging the therapy dose distribution using positron emission tomography (PET). The resulting PET images provide a powerful tool for quality assurance of ... continued below

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BEEBE - WANG,J.J.; DILMANIAN,F.A.; PEGGS,S.G.; SCHLYEER,D.J. & VASKA,P. June 3, 2002.

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Proton therapy is a treatment modality of increasing utility in clinical radiation oncology mostly because its dose distribution conforms more tightly to the target volume than x-ray radiation therapy. One important feature of proton therapy is that it produces a small amount of positron-emitting isotopes along the beam-path through the non-elastic nuclear interaction of protons with target nuclei such as {sup 12}C, {sup 14}N, and {sup 16}O. These radioisotopes, mainly {sup 11}C, {sup 13}N and {sup 15}O, allow imaging the therapy dose distribution using positron emission tomography (PET). The resulting PET images provide a powerful tool for quality assurance of the treatment, especially when treating inhomogeneous organs such as the lungs or the head-and-neck, where the calculation of the dose distribution for treatment planning is more difficult. This paper uses Monte Carlo simulations to predict the yield of positron emitters produced by a 250 MeV proton beam, and to simulate the productions of the image in a clinical PET scanner.

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3 pages

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  • EUROPEAN PARTICLE ACCELERATOR CONFERENCE 2002, PARIS (FR), 06/03/2002--06/07/2002

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  • Report No.: BNL--69406
  • Grant Number: AC02-98CH10886
  • Office of Scientific & Technical Information Report Number: 804610
  • Archival Resource Key: ark:/67531/metadc738843

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  • June 3, 2002

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  • Oct. 19, 2015, 7:39 p.m.

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  • Nov. 9, 2015, 12:08 p.m.

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BEEBE - WANG,J.J.; DILMANIAN,F.A.; PEGGS,S.G.; SCHLYEER,D.J. & VASKA,P. FEASIBILITY OF POSITRON EMISSION TOMOGRAPHY OF DOSE DISTRIBUTION IN PROTON BEAM CANCER THERAPY., article, June 3, 2002; Upton, New York. (digital.library.unt.edu/ark:/67531/metadc738843/: accessed July 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.