Probing the interaction of amphiphilic triblockcopolymers with a biomimetic membrane.

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In the last several years, there has been growing interest in the use of synthetic surfactants to augment cellular repair. Amphiphilic triblock copolymers such as PEO-PPO-PEO have been demonstrated to aid in the repair of a variety of cells. In spite of the reported success of these compounds in clinical trials, the mechanism of their interaction with cell membranes remains poorly understood. In this work, they describe their efforts to examine the effect of the mode of incorporation of triblock polyalkyleneoxide copolymers on membrane structure and stability. For this work, they have employed a model biomembrane whose structure and physical ... continued below

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Firestone, M. A. & Seifert, S. February 4, 2002.

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In the last several years, there has been growing interest in the use of synthetic surfactants to augment cellular repair. Amphiphilic triblock copolymers such as PEO-PPO-PEO have been demonstrated to aid in the repair of a variety of cells. In spite of the reported success of these compounds in clinical trials, the mechanism of their interaction with cell membranes remains poorly understood. In this work, they describe their efforts to examine the effect of the mode of incorporation of triblock polyalkyleneoxide copolymers on membrane structure and stability. For this work, they have employed a model biomembrane whose structure and physical properties have been previously determined. Several modes of polymer incorporation are examined: introduction via a membrane spanning triblock copolymer, grafting onto a phospholipid headgroup, or introduction via a partially inserted triblock copolymer. The polymer-membrane interactions are probed by small angle X-ray scattering and thermal analysis.

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  • 223rd ACS National Meeting, Orlando, FL (US), 04/07/2002--04/14/2002

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  • Report No.: ANL/MSD/CP-106836
  • Grant Number: W-31-109-ENG-38
  • Office of Scientific & Technical Information Report Number: 797893
  • Archival Resource Key: ark:/67531/metadc736996

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  • February 4, 2002

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  • Oct. 19, 2015, 7:39 p.m.

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  • March 30, 2016, 5:54 p.m.

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Firestone, M. A. & Seifert, S. Probing the interaction of amphiphilic triblockcopolymers with a biomimetic membrane., article, February 4, 2002; Illinois. (digital.library.unt.edu/ark:/67531/metadc736996/: accessed December 14, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.