Uncertainties in Organ Burdens Estimated from PAS

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To calculate committed effective dose equivalent, one needs to know the quantity of the radionuclide in all significantly irradiated organs (the organ burden) as a function of time following the intake. There are two major sources of uncertainty in an organ burden estimated from personal air sampling (PAS) data: (1) The uncertainty in going from the exposure measured with the PAS to the quantity of aerosol inhaled by the individual, and (2) The uncertainty in going from the intake to the organ burdens at any given time, taking into consideration the biological variability of the biokinetic models from person to ... continued below

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La Bone, T.R. February 2, 2004.

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To calculate committed effective dose equivalent, one needs to know the quantity of the radionuclide in all significantly irradiated organs (the organ burden) as a function of time following the intake. There are two major sources of uncertainty in an organ burden estimated from personal air sampling (PAS) data: (1) The uncertainty in going from the exposure measured with the PAS to the quantity of aerosol inhaled by the individual, and (2) The uncertainty in going from the intake to the organ burdens at any given time, taking into consideration the biological variability of the biokinetic models from person to person (interperson variability) and in one person over time (intra-person variability). We have been using biokinetic modeling methods developed by researchers at the University of Florida to explore the impact of inter-person variability on the uncertainty of organ burdens estimated from PAS data. These initial studies suggest that the uncertainties are so large that PAS might be considered to be a qualitative (rather than quantitative) technique. These results indicate that more studies should be performed to properly classify the reliability and usefulness of using PAS monitoring data to estimate organ burdens, organ dose, and ultimately CEDE.

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  • 2004 HPS Midyear Meeting, Augusta, GA (US), 02/08/2004--02/11/2004

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  • Report No.: WSRC-MS-2003-00494
  • Grant Number: AC09-96SR18500
  • Office of Scientific & Technical Information Report Number: 821203
  • Archival Resource Key: ark:/67531/metadc736414

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  • February 2, 2004

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  • Oct. 18, 2015, 6:40 p.m.

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  • May 5, 2016, 5:35 p.m.

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La Bone, T.R. Uncertainties in Organ Burdens Estimated from PAS, article, February 2, 2004; South Carolina. (digital.library.unt.edu/ark:/67531/metadc736414/: accessed September 25, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT Libraries Government Documents Department.